Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

EMBRACE Collaborators, GC-HBOC Study Collaborators, GEMO Study Collaborators, ABCTB Investigators, HEBON Investigators, BCFR Investigators

Research output: Contribution to journalArticle

Abstract

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.

Original languageEnglish (US)
Article number1741
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

genome
Genome-Wide Association Study
loci
Transcriptome
breast
genes
Genes
cancer
Breast Neoplasms
Quantitative Trait Loci
Tissue
estrogens
Estrogen Receptors
adipose tissues
etiology
spleen
Gene expression
gene expression
Adipose Tissue
Blood Cells

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

EMBRACE Collaborators, GC-HBOC Study Collaborators, GEMO Study Collaborators, ABCTB Investigators, HEBON Investigators, & BCFR Investigators (2019). Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. Nature communications, 10(1), [1741]. https://doi.org/10.1038/s41467-018-08053-5

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. / EMBRACE Collaborators; GC-HBOC Study Collaborators; GEMO Study Collaborators; ABCTB Investigators; HEBON Investigators; BCFR Investigators.

In: Nature communications, Vol. 10, No. 1, 1741, 01.12.2019.

Research output: Contribution to journalArticle

EMBRACE Collaborators, GC-HBOC Study Collaborators, GEMO Study Collaborators, ABCTB Investigators, HEBON Investigators & BCFR Investigators 2019, 'Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer', Nature communications, vol. 10, no. 1, 1741. https://doi.org/10.1038/s41467-018-08053-5
EMBRACE Collaborators, GC-HBOC Study Collaborators, GEMO Study Collaborators, ABCTB Investigators, HEBON Investigators, BCFR Investigators. Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. Nature communications. 2019 Dec 1;10(1). 1741. https://doi.org/10.1038/s41467-018-08053-5
EMBRACE Collaborators ; GC-HBOC Study Collaborators ; GEMO Study Collaborators ; ABCTB Investigators ; HEBON Investigators ; BCFR Investigators. / Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. In: Nature communications. 2019 ; Vol. 10, No. 1.
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