Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Espen Melum, Andre Franke, Christoph Schramm, Tobias J. Weismüller, Daniel Nils Gotthardt, Felix A. Offner, Brian D. Juran, Jon K. Laerdahl, Verena Labi, Einar Bjürnsson, Rinse K. Weersma, Liesbet Henckaerts, Andreas Teufel, Christian Rust, Eva Ellinghaus, Tobias Balschun, Kirsten Muri Boberg, David Ellinghaus, Annika Bergquist, Peter SauerEuijung Ryu, Johannes Roksund Hov, Jochen Wedemeyer, Björn Lindkvist, Michael Wittig, Robert J. Porte, Kristian Holm, Christian Gieger, H. Erich Wichmann, Pieter Stokkers, Cyriel Y. Ponsioen, Heiko Runz, Adolf Stiehl, Cisca Wijmenga, Martina Sterneck, Severine Vermeire, Ulrich Beuers, Andreas Villunger, Erik Schrumpf, Konstantinos N. Lazaridis, Michael P. Manns, Stefan Schreiber, Tom H. Karlsen

Research output: Contribution to journalArticle

166 Scopus citations

Abstract

Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4ĝ€"7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 ×- 10-16 and P = 4.1 ×- 10-8, respectively).

Original languageEnglish (US)
Pages (from-to)17-19
Number of pages3
JournalNature Genetics
Volume43
Issue number1
DOIs
StatePublished - Jan 2011

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci'. Together they form a unique fingerprint.

  • Cite this

    Melum, E., Franke, A., Schramm, C., Weismüller, T. J., Gotthardt, D. N., Offner, F. A., Juran, B. D., Laerdahl, J. K., Labi, V., Bjürnsson, E., Weersma, R. K., Henckaerts, L., Teufel, A., Rust, C., Ellinghaus, E., Balschun, T., Boberg, K. M., Ellinghaus, D., Bergquist, A., ... Karlsen, T. H. (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nature Genetics, 43(1), 17-19. https://doi.org/10.1038/ng.728