Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients

Richard B Kennedy, Inna G. Ovsyannikova, V. Shane Pankratz, Iana H. Haralambieva, Robert A. Vierkant, Gregory A. Poland

Research output: Contribution to journalArticle

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Abstract

The role that genetics play in response to infection or disease is becoming increasingly clear as we learn more about immunogenetics and host-pathogen interactions. Here we report a genome-wide analysis of the effects of host genetic variation on cytokine responses to vaccinia virus stimulation in smallpox vaccine recipients. Our data show that vaccinia stimulation of immune individuals results in secretion of inflammatory and Th1 cytokines. We identified multiple SNPs significantly associated with variations in cytokine secretion. These SNPs are found in genes with known immune function, as well as in genes encoding for proteins involved in signal transduction, cytoskeleton, membrane channels and ion transport, as well as others with no previously identified connection to immune responses. The large number of significant SNP associations implies that cytokine secretion in response to vaccinia virus is a complex process controlled by multiple genes and gene families. Follow-up studies to replicate these findings and then pursue mechanistic studies will provide a greater understanding of how genetic variation influences vaccine responses.

Original languageEnglish (US)
Pages (from-to)1403-1421
Number of pages19
JournalHuman Genetics
Volume131
Issue number9
DOIs
StatePublished - Sep 2012

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Smallpox Vaccine
Genome
Cytokines
Single Nucleotide Polymorphism
Vaccinia virus
Genes
Host-Pathogen Interactions
Vaccinia
Immunogenetics
Ion Transport
Cytoskeleton
Ion Channels
Signal Transduction
Vaccines
Infection
Proteins

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Kennedy, R. B., Ovsyannikova, I. G., Shane Pankratz, V., Haralambieva, I. H., Vierkant, R. A., & Poland, G. A. (2012). Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. Human Genetics, 131(9), 1403-1421. https://doi.org/10.1007/s00439-012-1174-2

Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. / Kennedy, Richard B; Ovsyannikova, Inna G.; Shane Pankratz, V.; Haralambieva, Iana H.; Vierkant, Robert A.; Poland, Gregory A.

In: Human Genetics, Vol. 131, No. 9, 09.2012, p. 1403-1421.

Research output: Contribution to journalArticle

Kennedy, RB, Ovsyannikova, IG, Shane Pankratz, V, Haralambieva, IH, Vierkant, RA & Poland, GA 2012, 'Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients', Human Genetics, vol. 131, no. 9, pp. 1403-1421. https://doi.org/10.1007/s00439-012-1174-2
Kennedy, Richard B ; Ovsyannikova, Inna G. ; Shane Pankratz, V. ; Haralambieva, Iana H. ; Vierkant, Robert A. ; Poland, Gregory A. / Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. In: Human Genetics. 2012 ; Vol. 131, No. 9. pp. 1403-1421.
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