Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases

International Parkinson's Disease Genomics Consortium (IPDGC)

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.

Original languageEnglish (US)
Pages (from-to)214.e7-214.e10
JournalNeurobiology of aging
Volume38
DOIs
StatePublished - Oct 13 2016

Keywords

  • Alzheimer's disease
  • Dementia with Lewy bodies
  • Genetic correlation
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology

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