TY - JOUR
T1 - Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases
AU - International Parkinson's Disease Genomics Consortium (IPDGC)
AU - Guerreiro, Rita
AU - Escott-Price, Valentina
AU - Darwent, Lee
AU - Parkkinen, Laura
AU - Ansorge, Olaf
AU - Hernandez, Dena G.
AU - Nalls, Michael A.
AU - Clark, Lorraine
AU - Honig, Lawrence
AU - Marder, Karen
AU - van der Flier, Wiesje
AU - Holstege, Henne
AU - Louwersheimer, Eva
AU - Lemstra, Afina
AU - Scheltens, Philip
AU - Rogaeva, Ekaterina
AU - St George-Hyslop, Peter
AU - Londos, Elisabet
AU - Zetterberg, Henrik
AU - Ortega-Cubero, Sara
AU - Pastor, Pau
AU - Ferman, Tanis J.
AU - Graff-Radford, Neill R.
AU - Ross, Owen A.
AU - Barber, Imelda
AU - Braae, Anne
AU - Brown, Kristelle
AU - Morgan, Kevin
AU - Maetzler, Walter
AU - Berg, Daniela
AU - Troakes, Claire
AU - Al-Sarraj, Safa
AU - Lashley, Tammaryn
AU - Compta, Yaroslau
AU - Revesz, Tamas
AU - Lees, Andrew
AU - Cairns, Nigel J.
AU - Halliday, Glenda M.
AU - Mann, David
AU - Pickering-Brown, Stuart
AU - Powell, John
AU - Lunnon, Katie
AU - Lupton, Michelle K.
AU - Dickson, Dennis
AU - Hardy, John
AU - Singleton, Andrew
AU - Bras, Jose
N1 - Publisher Copyright:
© 2016 The Authors.
PY - 2016/10/13
Y1 - 2016/10/13
N2 - The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.
AB - The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.
KW - Alzheimer's disease
KW - Dementia with Lewy bodies
KW - Genetic correlation
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=84948808791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84948808791&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2015.10.028
DO - 10.1016/j.neurobiolaging.2015.10.028
M3 - Article
C2 - 26643944
AN - SCOPUS:84948808791
SN - 0197-4580
VL - 38
SP - 214.e7-214.e10
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -