Genome scan for linkage to asthma using a linkage disequilibrium-lod score test

Y. Jiang, S. L. Slager, J. Huang

Research output: Contribution to journalArticlepeer-review

Abstract

We report a genome-wide linkage study of asthma on the German and Collaborative Study on the Genetics of Asthma (CSGA) data. Using a combined linkage and linkage disequilibrium test and the nonparametric linkage score, we identified 13 markers from the German data, 1 marker from the African American (CSGA) data, and 7 markers from the Caucasian (CSGA) data in which the p-values ranged between 0.0001 and 0.0100. From our analysis and taking into account previous published linkage studies of asthma, we suggest that three regions in chromosome 5 (around D5S418, D5S644, and D5S422), one region in chromosome 6 (around three neighboring markers D6S1281, D6S291, and D6S1019), one region in chromosome 11 (around D11S2362), and two regions in chromosome 12 (around D12S351 and D12S324) especially merit further investigation.

Original languageEnglish (US)
Pages (from-to)S303-S307
JournalGenetic epidemiology
Volume21
Issue numberSUPPL. 1
DOIs
StatePublished - 2001

Keywords

  • Adaptive combination
  • Linkage
  • TDT

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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