TY - JOUR
T1 - Genome scan for linkage to asthma using a linkage disequilibrium-lod score test
AU - Jiang, Y.
AU - Slager, S. L.
AU - Huang, J.
PY - 2001
Y1 - 2001
N2 - We report a genome-wide linkage study of asthma on the German and Collaborative Study on the Genetics of Asthma (CSGA) data. Using a combined linkage and linkage disequilibrium test and the nonparametric linkage score, we identified 13 markers from the German data, 1 marker from the African American (CSGA) data, and 7 markers from the Caucasian (CSGA) data in which the p-values ranged between 0.0001 and 0.0100. From our analysis and taking into account previous published linkage studies of asthma, we suggest that three regions in chromosome 5 (around D5S418, D5S644, and D5S422), one region in chromosome 6 (around three neighboring markers D6S1281, D6S291, and D6S1019), one region in chromosome 11 (around D11S2362), and two regions in chromosome 12 (around D12S351 and D12S324) especially merit further investigation.
AB - We report a genome-wide linkage study of asthma on the German and Collaborative Study on the Genetics of Asthma (CSGA) data. Using a combined linkage and linkage disequilibrium test and the nonparametric linkage score, we identified 13 markers from the German data, 1 marker from the African American (CSGA) data, and 7 markers from the Caucasian (CSGA) data in which the p-values ranged between 0.0001 and 0.0100. From our analysis and taking into account previous published linkage studies of asthma, we suggest that three regions in chromosome 5 (around D5S418, D5S644, and D5S422), one region in chromosome 6 (around three neighboring markers D6S1281, D6S291, and D6S1019), one region in chromosome 11 (around D11S2362), and two regions in chromosome 12 (around D12S351 and D12S324) especially merit further investigation.
KW - Adaptive combination
KW - Linkage
KW - TDT
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U2 - 10.1002/gepi.2001.21.s1.s303
DO - 10.1002/gepi.2001.21.s1.s303
M3 - Article
C2 - 11793688
AN - SCOPUS:0034793163
SN - 0741-0395
VL - 21
SP - S303-S307
JO - Genetic epidemiology
JF - Genetic epidemiology
IS - SUPPL. 1
ER -