Genital soft tissue tumors

J. Kenneth Schoolmeester, Karen J. Fritchie

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Mesenchymal neoplasms of the vulvovaginal and inguinoscrotal regions are among the most diagnostically challenging specimens in the pathology laboratory owing largely to their unique intersection between general soft tissue tumors and relatively genital-specific mesenchymal tumors. Genital stromal tumors are a unique subset of soft tissue tumors encountered at this location, and this group includes fibroepithelial stromal polyp, superficial (cervicovaginal) myofibroblastoma, cellular angiofibroma, mammary-type myofibroblastoma, angiomyofibroblastoma and aggressive angiomyxoma. Aside from the striking morphologic and immunophenotypic similarity that is seen with these entities, there is evidence that a subset of genital stromal tumors may be linked genetically. This review will focus on simplifying this group of tumors and provide the pathologist or dermatopathologist with practical management information. Smooth muscle tumors of the external genitalia will also be discussed.

Original languageEnglish (US)
Pages (from-to)441-451
Number of pages11
JournalJournal of Cutaneous Pathology
Volume42
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • angiomyofibroblastoma
  • angiomyxoma
  • cellular angiofibroma
  • genital stromal tumors
  • smooth muscle tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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