Abstract
Genetic studies are transforming the way we diagnose, evaluate and treat patients. The era of genome-wide association studies promised to discover common risk variants in heterogeneous disorders where previous small-scale association studies had on the whole failed. However, as we enter the post-association era a degree of disappointment is felt regarding the lack of risk factors with large effect for a number of disorders including vascular diseases. Vascular disorders are sporadic by nature, though a familial component has been observed. This review will focus on vascular dementia, the genetic risk factors for vascular disorders and highlight how new technologies may overcome the limitations of genome-wide association and nominate those genes that influence disease risk.
Original language | English (US) |
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Pages (from-to) | 9-25 |
Number of pages | 17 |
Journal | Minerva Psichiatrica |
Volume | 51 |
Issue number | 1 |
State | Published - Mar 2010 |
Keywords
- Dementia, vascular
- Genetics
- Vascular diseases
ASJC Scopus subject areas
- Psychiatry and Mental health