Genetics of vascular dementia

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Genetic studies are transforming the way we diagnose, evaluate and treat patients. The era of genome-wide association studies promised to discover common risk variants in heterogeneous disorders where previous small-scale association studies had on the whole failed. However, as we enter the post-association era a degree of disappointment is felt regarding the lack of risk factors with large effect for a number of disorders including vascular diseases. Vascular disorders are sporadic by nature, though a familial component has been observed. This review will focus on vascular dementia, the genetic risk factors for vascular disorders and highlight how new technologies may overcome the limitations of genome-wide association and nominate those genes that influence disease risk.

Original languageEnglish (US)
Pages (from-to)9-25
Number of pages17
JournalMinerva Psichiatrica
Volume51
Issue number1
StatePublished - Mar 2010

Keywords

  • Dementia, vascular
  • Genetics
  • Vascular diseases

ASJC Scopus subject areas

  • Psychiatry and Mental health

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