Genetics of type 2 diabetes

Galina Smushkin, Adrian Vella

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose of review: To provide an overview of the genetics of type 2 diabetes in the context of recent progress in the understanding of the genetic architecture of the disease and its applicability to the pathogenesis of the disease as well as efforts to individualize therapy in type 2 diabetes. Efforts are underway to understand how these loci alter measurable physiologic processes in nondiabetic humans. However, it is important to understand the potential pitfalls in such studies and the limitations underlying measurement of insulin secretion and action using qualitative methodologies. Recent findings: The availability of large population-based cohorts and the ease with which large numbers of common genetic variants can be genotyped has enabled the discovery of multiple loci and pathways associated with type 2 diabetes. Recent efforts examining quantitative traits such as fasting glucose concentrations have led to the discovery of other genes likely to be important in the development of diabetes. Summary: The past 4 years have witnessed a significant increase in our understanding of genetic predisposition to type 2 diabetes. Hopefully more progress will be made in applying this knowledge to the pathophysiology of type 2 diabetes in the coming years.

Original languageEnglish (US)
Pages (from-to)471-477
Number of pages7
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Volume13
Issue number4
DOIs
StatePublished - Jul 2010

Fingerprint

Type 2 Diabetes Mellitus
Inborn Genetic Diseases
Genetic Association Studies
Genetic Predisposition to Disease
Fasting
Insulin
Glucose
Population
Therapeutics

Keywords

  • genetic predisposition
  • quantitative traits
  • type 2 diabetes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Genetics of type 2 diabetes. / Smushkin, Galina; Vella, Adrian.

In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 13, No. 4, 07.2010, p. 471-477.

Research output: Contribution to journalArticle

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