Genetics of pancreatic cancer: From genes to families

R. H. Hruban, Gloria M Petersen, P. K. Ha, S. E. Kern

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Cancer of the pancreas is a genetic disease. Sporadic cancers of the pancreas are frequently associated with the activation of an oncogene, K- ras, and the inactivation of multiple tumor suppressor genes, including p53, DPC4, p16, and BRCA2. An improved understanding of the genetics of pancreas cancer should lead to new tests to screen for this disease and novel rational gene-based therapies.

Original languageEnglish (US)
Pages (from-to)1-23
Number of pages23
JournalSurgical Oncology Clinics of North America
Volume7
Issue number1
StatePublished - 1998
Externally publishedYes

Fingerprint

Neoplasm Genes
Pancreatic Neoplasms
Inborn Genetic Diseases
ras Genes
Tumor Suppressor Genes
Genetic Therapy

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Genetics of pancreatic cancer : From genes to families. / Hruban, R. H.; Petersen, Gloria M; Ha, P. K.; Kern, S. E.

In: Surgical Oncology Clinics of North America, Vol. 7, No. 1, 1998, p. 1-23.

Research output: Contribution to journalArticle

Hruban, R. H. ; Petersen, Gloria M ; Ha, P. K. ; Kern, S. E. / Genetics of pancreatic cancer : From genes to families. In: Surgical Oncology Clinics of North America. 1998 ; Vol. 7, No. 1. pp. 1-23.
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