Genetics of pancreatic cancer: From genes to families

R. H. Hruban, G. M. Petersen, P. K. Ha, S. E. Kern

Research output: Contribution to journalReview article

152 Scopus citations

Abstract

Cancer of the pancreas is a genetic disease. Sporadic cancers of the pancreas are frequently associated with the activation of an oncogene, K- ras, and the inactivation of multiple tumor suppressor genes, including p53, DPC4, p16, and BRCA2. An improved understanding of the genetics of pancreas cancer should lead to new tests to screen for this disease and novel rational gene-based therapies.

Original languageEnglish (US)
Pages (from-to)1-23
Number of pages23
JournalSurgical Oncology Clinics of North America
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Surgery
  • Oncology

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