Abstract
Despite considerable progress in the understanding of clinical and pathological features of Parkinson’s disease (PD), the etiology of this condition remains unknown (1,2). There are two major plausible explanations on which current working hypotheses are based. The “environmental hypothesis,” widely propagated in the 1980s, appears to have had only limited influence (3). The scope of environmental factors on causation of PD is discussed in Chapter 15. The “genetic hypothesis,” which was popular in the 1990s, stemmed from significant progress in the development of new molecular genetic techniques and from the description of several large families with a phenotype closely resembling that of sporadic PD (4,5). However, genetic factors still do not explain the etiology of all cases of PD (6). It is reasonable to assume that a combination of environmental and inherited risk factors plays the crucial role in developing disease in most cases of parkinsonism. The era of exploration of these intermingling influences and factors is just beginning.
| Original language | English (US) |
|---|---|
| Title of host publication | Handbook of Parkinson's Disease, Third Edition |
| Publisher | CRC Press |
| Pages | 325-337 |
| Number of pages | 13 |
| ISBN (Electronic) | 9780203912164 |
| ISBN (Print) | 9780824742423 |
| State | Published - Jan 1 2003 |
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ASJC Scopus subject areas
- Medicine(all)
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Genetics. / Wszolek, Zbigniew K; Farrer, Matthew.
Handbook of Parkinson's Disease, Third Edition. CRC Press, 2003. p. 325-337.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Genetics
AU - Wszolek, Zbigniew K
AU - Farrer, Matthew
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Despite considerable progress in the understanding of clinical and pathological features of Parkinson’s disease (PD), the etiology of this condition remains unknown (1,2). There are two major plausible explanations on which current working hypotheses are based. The “environmental hypothesis,” widely propagated in the 1980s, appears to have had only limited influence (3). The scope of environmental factors on causation of PD is discussed in Chapter 15. The “genetic hypothesis,” which was popular in the 1990s, stemmed from significant progress in the development of new molecular genetic techniques and from the description of several large families with a phenotype closely resembling that of sporadic PD (4,5). However, genetic factors still do not explain the etiology of all cases of PD (6). It is reasonable to assume that a combination of environmental and inherited risk factors plays the crucial role in developing disease in most cases of parkinsonism. The era of exploration of these intermingling influences and factors is just beginning.
AB - Despite considerable progress in the understanding of clinical and pathological features of Parkinson’s disease (PD), the etiology of this condition remains unknown (1,2). There are two major plausible explanations on which current working hypotheses are based. The “environmental hypothesis,” widely propagated in the 1980s, appears to have had only limited influence (3). The scope of environmental factors on causation of PD is discussed in Chapter 15. The “genetic hypothesis,” which was popular in the 1990s, stemmed from significant progress in the development of new molecular genetic techniques and from the description of several large families with a phenotype closely resembling that of sporadic PD (4,5). However, genetic factors still do not explain the etiology of all cases of PD (6). It is reasonable to assume that a combination of environmental and inherited risk factors plays the crucial role in developing disease in most cases of parkinsonism. The era of exploration of these intermingling influences and factors is just beginning.
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M3 - Chapter
AN - SCOPUS:1842448963
SN - 9780824742423
SP - 325
EP - 337
BT - Handbook of Parkinson's Disease, Third Edition
PB - CRC Press
ER -