TY - JOUR
T1 - Genetic/familial high-risk assessment
T2 - Colorectal version 1.2016: Clinical practice guidelines in oncology
AU - Provenzale, Dawn
AU - Gupta, Samir
AU - Ahnen, Dennis J.
AU - Bray, Travis
AU - Cannon, Jamie A.
AU - Cooper, Gregory
AU - David, Donald S.
AU - Early, Dayna S.
AU - Erwin, Deborah
AU - Ford, James M.
AU - Giardiello, Francis M.
AU - Grady, William
AU - Halverson, Amy L.
AU - Hamilton, Stanley R.
AU - Hampel, Heather
AU - Ismail, Mohammad K.
AU - Klapman, Jason B.
AU - Larson, David W.
AU - Lazenby, Audrey J.
AU - Lynch, Patrick M.
AU - Mayer, Robert J.
AU - Ness, Reid M.
AU - Regenbogen, Scott E.
AU - Samadder, Niloy Jewel
AU - Shike, Moshe
AU - Steinbach, Gideon
AU - Weinberg, David
AU - Dwyer, Mary
AU - Darlow, Susan
PY - 2016/8/1
Y1 - 2016/8/1
N2 - This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.
AB - This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.
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U2 - 10.6004/jnccn.2016.0108
DO - 10.6004/jnccn.2016.0108
M3 - Article
C2 - 27496117
AN - SCOPUS:84982980766
SN - 1540-1405
VL - 14
SP - 1010
EP - 1030
JO - JNCCN Journal of the National Comprehensive Cancer Network
JF - JNCCN Journal of the National Comprehensive Cancer Network
IS - 8
ER -