TY - JOUR
T1 - Genetically augmented tissue engineering of the musculoskeletal system
AU - Evans, C. H.
AU - Robbins, P. D.
PY - 1999
Y1 - 1999
N2 - Recent advances in gene transfer technology permit the design of strategies to improve the outcome of orthopaedic tissue engineering by genetic means. Using ex vivo and in vivo strategies, genes have been transferred successfully to, and expressed within, numerous tissues of the musculoskeletal system, including articular cartilage, meniscus, intervertebral disc, bone, tendon, ligament, synovium, and muscle. With these technologies, various genes encoding modulatory species of ribonucleic acid or proteins such as growth factors, receptors, and transcription factors could be used in the context of genetically augmented tissue engineering. Proof of principle has been established in numerous animal models, and a human protocol for the transfer of genes to synovium already is underway. Progress so far permits cautious optimism of a successful outcome to these pursuits.
AB - Recent advances in gene transfer technology permit the design of strategies to improve the outcome of orthopaedic tissue engineering by genetic means. Using ex vivo and in vivo strategies, genes have been transferred successfully to, and expressed within, numerous tissues of the musculoskeletal system, including articular cartilage, meniscus, intervertebral disc, bone, tendon, ligament, synovium, and muscle. With these technologies, various genes encoding modulatory species of ribonucleic acid or proteins such as growth factors, receptors, and transcription factors could be used in the context of genetically augmented tissue engineering. Proof of principle has been established in numerous animal models, and a human protocol for the transfer of genes to synovium already is underway. Progress so far permits cautious optimism of a successful outcome to these pursuits.
UR - http://www.scopus.com/inward/record.url?scp=0032709326&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032709326&partnerID=8YFLogxK
U2 - 10.1097/00003086-199910001-00040
DO - 10.1097/00003086-199910001-00040
M3 - Article
C2 - 10546663
AN - SCOPUS:0032709326
SN - 0009-921X
VL - 367
SP - S410-S418
JO - Clinical orthopaedics and related research
JF - Clinical orthopaedics and related research
IS - SUPPL.
ER -