Genetically augmented tissue engineering of the musculoskeletal system

Christopher H Evans, P. D. Robbins

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Recent advances in gene transfer technology permit the design of strategies to improve the outcome of orthopaedic tissue engineering by genetic means. Using ex vivo and in vivo strategies, genes have been transferred successfully to, and expressed within, numerous tissues of the musculoskeletal system, including articular cartilage, meniscus, intervertebral disc, bone, tendon, ligament, synovium, and muscle. With these technologies, various genes encoding modulatory species of ribonucleic acid or proteins such as growth factors, receptors, and transcription factors could be used in the context of genetically augmented tissue engineering. Proof of principle has been established in numerous animal models, and a human protocol for the transfer of genes to synovium already is underway. Progress so far permits cautious optimism of a successful outcome to these pursuits.

Original languageEnglish (US)
JournalClinical Orthopaedics and Related Research
Issue number367 SUPPL.
StatePublished - 1999
Externally publishedYes

Fingerprint

Musculoskeletal System
Tissue Engineering
Synovial Membrane
Genes
Technology Transfer
Growth Factor Receptors
Intervertebral Disc
Articular Cartilage
Ligaments
Tendons
Orthopedics
Transcription Factors
Animal Models
RNA
Technology
Bone and Bones
Muscles
Proteins

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Genetically augmented tissue engineering of the musculoskeletal system. / Evans, Christopher H; Robbins, P. D.

In: Clinical Orthopaedics and Related Research, No. 367 SUPPL., 1999.

Research output: Contribution to journalArticle

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