Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease

Barbara Shannon, Alexandra Soto-Ortolaza, Sruti Rayaprolu, Heather D. Cannon, Catherine Labbé, Bruno A. Benitez, Jiyoon Choi, Timothy Lynch, Magdalena Boczarska-Jedynak, Grzegorz Opala, Anna Krygowska-Wajs, Maria Barcikowska, Jay A Van Gerpen, Ryan J. Uitti, Wolfdieter Springer, Carlos Cruchaga, Zbigniew K Wszolek, Owen A Ross

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We recently showed that mutation of the VPS35 gene can cause late-onset Parkinson's disease. In the present study we sequenced 702 affected subjects from the Mayo Clinic Parkinson's disease patient-control series for the VPS29 and VPS26A/B genes. We identified only 2 rare nonsynonymous variants in the VPS26A p.K93E and VPS29 p.N72H. The results show that mutations in the genes composing the retromer cargo recognition subunit are not a common cause of Parkinson's disease.

Original languageEnglish (US)
JournalNeurobiology of Aging
Volume35
Issue number8
DOIs
StatePublished - 2014

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Parkinson Disease
Genes
Mutation
Late Onset Disorders

Keywords

  • Genetics
  • Parkinson's disease and/or Parkinsonism
  • Retromer
  • VPS35

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease. / Shannon, Barbara; Soto-Ortolaza, Alexandra; Rayaprolu, Sruti; Cannon, Heather D.; Labbé, Catherine; Benitez, Bruno A.; Choi, Jiyoon; Lynch, Timothy; Boczarska-Jedynak, Magdalena; Opala, Grzegorz; Krygowska-Wajs, Anna; Barcikowska, Maria; Van Gerpen, Jay A; Uitti, Ryan J.; Springer, Wolfdieter; Cruchaga, Carlos; Wszolek, Zbigniew K; Ross, Owen A.

In: Neurobiology of Aging, Vol. 35, No. 8, 2014.

Research output: Contribution to journalArticle

Shannon, B, Soto-Ortolaza, A, Rayaprolu, S, Cannon, HD, Labbé, C, Benitez, BA, Choi, J, Lynch, T, Boczarska-Jedynak, M, Opala, G, Krygowska-Wajs, A, Barcikowska, M, Van Gerpen, JA, Uitti, RJ, Springer, W, Cruchaga, C, Wszolek, ZK & Ross, OA 2014, 'Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease', Neurobiology of Aging, vol. 35, no. 8. https://doi.org/10.1016/j.neurobiolaging.2014.03.004
Shannon, Barbara ; Soto-Ortolaza, Alexandra ; Rayaprolu, Sruti ; Cannon, Heather D. ; Labbé, Catherine ; Benitez, Bruno A. ; Choi, Jiyoon ; Lynch, Timothy ; Boczarska-Jedynak, Magdalena ; Opala, Grzegorz ; Krygowska-Wajs, Anna ; Barcikowska, Maria ; Van Gerpen, Jay A ; Uitti, Ryan J. ; Springer, Wolfdieter ; Cruchaga, Carlos ; Wszolek, Zbigniew K ; Ross, Owen A. / Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease. In: Neurobiology of Aging. 2014 ; Vol. 35, No. 8.
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abstract = "We recently showed that mutation of the VPS35 gene can cause late-onset Parkinson's disease. In the present study we sequenced 702 affected subjects from the Mayo Clinic Parkinson's disease patient-control series for the VPS29 and VPS26A/B genes. We identified only 2 rare nonsynonymous variants in the VPS26A p.K93E and VPS29 p.N72H. The results show that mutations in the genes composing the retromer cargo recognition subunit are not a common cause of Parkinson's disease.",
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AU - Labbé, Catherine

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AU - Choi, Jiyoon

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AU - Boczarska-Jedynak, Magdalena

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AU - Barcikowska, Maria

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AU - Ross, Owen A

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AB - We recently showed that mutation of the VPS35 gene can cause late-onset Parkinson's disease. In the present study we sequenced 702 affected subjects from the Mayo Clinic Parkinson's disease patient-control series for the VPS29 and VPS26A/B genes. We identified only 2 rare nonsynonymous variants in the VPS26A p.K93E and VPS29 p.N72H. The results show that mutations in the genes composing the retromer cargo recognition subunit are not a common cause of Parkinson's disease.

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