Genetic variation of Omi/HtrA2 and Parkinson's disease

Owen A Ross, Alexandra I. Soto, Carles Vilariño-Güell, Michael G. Heckman, Nancy N. Diehl, Mary M. Hulihan, Jan O. Aasly, Sigrid Sando, J. Mark Gibson, Timothy Lynch, Anna Krygowska-Wajs, Grzegorz Opala, Maria Barcikowska, Krzysztof Czyzewski, Ryan J. Uitti, Zbigniew K Wszolek, Matthew J. Farrer

Research output: Contribution to journalArticle

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Abstract

Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n = 2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)539-543
Number of pages5
JournalParkinsonism and Related Disorders
Volume14
Issue number7
DOIs
StatePublished - Nov 2008

Fingerprint

Parkinson Disease
Genes
Mutation
Parkinson Disease, Familial, Type 1

Keywords

  • HtrA2
  • Mitochondria
  • Neurodegeneration
  • PARK13
  • PD

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Ross, O. A., Soto, A. I., Vilariño-Güell, C., Heckman, M. G., Diehl, N. N., Hulihan, M. M., ... Farrer, M. J. (2008). Genetic variation of Omi/HtrA2 and Parkinson's disease. Parkinsonism and Related Disorders, 14(7), 539-543. https://doi.org/10.1016/j.parkreldis.2008.08.003

Genetic variation of Omi/HtrA2 and Parkinson's disease. / Ross, Owen A; Soto, Alexandra I.; Vilariño-Güell, Carles; Heckman, Michael G.; Diehl, Nancy N.; Hulihan, Mary M.; Aasly, Jan O.; Sando, Sigrid; Gibson, J. Mark; Lynch, Timothy; Krygowska-Wajs, Anna; Opala, Grzegorz; Barcikowska, Maria; Czyzewski, Krzysztof; Uitti, Ryan J.; Wszolek, Zbigniew K; Farrer, Matthew J.

In: Parkinsonism and Related Disorders, Vol. 14, No. 7, 11.2008, p. 539-543.

Research output: Contribution to journalArticle

Ross, OA, Soto, AI, Vilariño-Güell, C, Heckman, MG, Diehl, NN, Hulihan, MM, Aasly, JO, Sando, S, Gibson, JM, Lynch, T, Krygowska-Wajs, A, Opala, G, Barcikowska, M, Czyzewski, K, Uitti, RJ, Wszolek, ZK & Farrer, MJ 2008, 'Genetic variation of Omi/HtrA2 and Parkinson's disease', Parkinsonism and Related Disorders, vol. 14, no. 7, pp. 539-543. https://doi.org/10.1016/j.parkreldis.2008.08.003
Ross OA, Soto AI, Vilariño-Güell C, Heckman MG, Diehl NN, Hulihan MM et al. Genetic variation of Omi/HtrA2 and Parkinson's disease. Parkinsonism and Related Disorders. 2008 Nov;14(7):539-543. https://doi.org/10.1016/j.parkreldis.2008.08.003
Ross, Owen A ; Soto, Alexandra I. ; Vilariño-Güell, Carles ; Heckman, Michael G. ; Diehl, Nancy N. ; Hulihan, Mary M. ; Aasly, Jan O. ; Sando, Sigrid ; Gibson, J. Mark ; Lynch, Timothy ; Krygowska-Wajs, Anna ; Opala, Grzegorz ; Barcikowska, Maria ; Czyzewski, Krzysztof ; Uitti, Ryan J. ; Wszolek, Zbigniew K ; Farrer, Matthew J. / Genetic variation of Omi/HtrA2 and Parkinson's disease. In: Parkinsonism and Related Disorders. 2008 ; Vol. 14, No. 7. pp. 539-543.
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