Genetic variation of Omi/HtrA2 and Parkinson's disease

Owen A. Ross, Alexandra I. Soto, Carles Vilariño-Güell, Michael G. Heckman, Nancy N. Diehl, Mary M. Hulihan, Jan O. Aasly, Sigrid Sando, J. Mark Gibson, Timothy Lynch, Anna Krygowska-Wajs, Grzegorz Opala, Maria Barcikowska, Krzysztof Czyzewski, Ryan J. Uitti, Zbigniew K. Wszolek, Matthew J. Farrer

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n = 2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)539-543
Number of pages5
JournalParkinsonism and Related Disorders
Volume14
Issue number7
DOIs
StatePublished - Nov 2008

Keywords

  • HtrA2
  • Mitochondria
  • Neurodegeneration
  • PARK13
  • PD

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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    Ross, O. A., Soto, A. I., Vilariño-Güell, C., Heckman, M. G., Diehl, N. N., Hulihan, M. M., Aasly, J. O., Sando, S., Gibson, J. M., Lynch, T., Krygowska-Wajs, A., Opala, G., Barcikowska, M., Czyzewski, K., Uitti, R. J., Wszolek, Z. K., & Farrer, M. J. (2008). Genetic variation of Omi/HtrA2 and Parkinson's disease. Parkinsonism and Related Disorders, 14(7), 539-543. https://doi.org/10.1016/j.parkreldis.2008.08.003