Genetic variation in the transforming growth factor β1 gene in multiple sclerosis

Brian G. Weinshenker, David Hebrink, Orhun H. Kantarci, Janet Schaefer-Klein, Elizabeth Atkinson, Daniel Schaid, Cynthia M. McMurray

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Transforming growth factor β1 (TGFβ1) is a Th2 cytokine encoded on chromosome 19q13, a region possibly linked to multiple sclerosis (MS). TGFβ1 exerts favorable effects on experimental allergic encephalomyelitis. We performed a comprehensive search for genetic variants in this gene in 122 population-based sporadic cases of MS. We detected six variants, including three missense variants. We tested for association of the variants with susceptibility and course of MS and for linkage and transmission disequilibrium in a family series consisting of 395 samples in 59 pedigrees. Genetic variation in TGFB1 does not appear to contribute in a major way to susceptibility to MS.

Original languageEnglish (US)
Pages (from-to)138-145
Number of pages8
JournalJournal of neuroimmunology
Volume120
Issue number1-2
DOIs
StatePublished - 2001

Keywords

  • Multiple sclerosis
  • Neurogenetics
  • Neuroimmunology
  • Transforming growth factor β1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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