TY - JOUR
T1 - Genetic variation in the transforming growth factor β1 gene in multiple sclerosis
AU - Weinshenker, Brian G.
AU - Hebrink, David
AU - Kantarci, Orhun H.
AU - Schaefer-Klein, Janet
AU - Atkinson, Elizabeth
AU - Schaid, Daniel
AU - McMurray, Cynthia M.
N1 - Funding Information:
This work was supported by grant RG2870-A-2 from the National Multiple Sclerosis Society to BGW. OHK is supported by a fellowship grant from the National Multiple Sclerosis Society. CTM is supported by NIH (R01 DK 46394-3 and R01 MH 56207-1) and by the National Science Foundation (IBN-92-22848-5). We greatly appreciate the cooperation of Dr. S. Hauser, University of California, San Francisco, who provided DNA samples and pedigree structures for the familial cases tested. Mrs. Laura Irlbeck typed the manuscript. This work was presented in part at the 1999 American Society of Human Genetics meeting, San Francisco, CA.
PY - 2001
Y1 - 2001
N2 - Transforming growth factor β1 (TGFβ1) is a Th2 cytokine encoded on chromosome 19q13, a region possibly linked to multiple sclerosis (MS). TGFβ1 exerts favorable effects on experimental allergic encephalomyelitis. We performed a comprehensive search for genetic variants in this gene in 122 population-based sporadic cases of MS. We detected six variants, including three missense variants. We tested for association of the variants with susceptibility and course of MS and for linkage and transmission disequilibrium in a family series consisting of 395 samples in 59 pedigrees. Genetic variation in TGFB1 does not appear to contribute in a major way to susceptibility to MS.
AB - Transforming growth factor β1 (TGFβ1) is a Th2 cytokine encoded on chromosome 19q13, a region possibly linked to multiple sclerosis (MS). TGFβ1 exerts favorable effects on experimental allergic encephalomyelitis. We performed a comprehensive search for genetic variants in this gene in 122 population-based sporadic cases of MS. We detected six variants, including three missense variants. We tested for association of the variants with susceptibility and course of MS and for linkage and transmission disequilibrium in a family series consisting of 395 samples in 59 pedigrees. Genetic variation in TGFB1 does not appear to contribute in a major way to susceptibility to MS.
KW - Multiple sclerosis
KW - Neurogenetics
KW - Neuroimmunology
KW - Transforming growth factor β1
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U2 - 10.1016/S0165-5728(01)00424-6
DO - 10.1016/S0165-5728(01)00424-6
M3 - Article
C2 - 11694328
AN - SCOPUS:0034750527
SN - 0165-5728
VL - 120
SP - 138
EP - 145
JO - Journal of neuroimmunology
JF - Journal of neuroimmunology
IS - 1-2
ER -