TY - JOUR
T1 - Genetic variation in the B7-1 gene in patients with multiple sclerosis
AU - Weinshenker, Brian G.
AU - Hebrink, David D.
AU - Klein, Christopher
AU - Atkinson, Elizabeth J.
AU - O'Brien, Peter C.
AU - McMurray, Cynthia T.
N1 - Funding Information:
This work was supported by grant RG2870-A-2 from the National Multiple Sclerosis Society to BGW. CTM is supported by NIH (R01 DK 46394-3 and R01 MH 56207-1) and by the National Science Foundation (IBN-92-22848-5). Mrs. Laura Irlbeck typed the manuscript. This work was presented as poster 2110 at the 1998 American Society of Human Genetics meeting, Baltimore, MD.
PY - 2000/6/26
Y1 - 2000/6/26
N2 - Co-stimulation of T cells by B7-1, a protein that is expressed on antigen presenting cells, favors a T helper type1 (Th1) cellular response. Th1/Th2 bias may influence disease susceptibility or course of MS. We screened the entire coding sequence as well as the 5'- and 3'-untranslated regions of the B7-1 gene using a mutation scanning technique, dideoxyfingerprinting, in DNA from 111 patients with MS from Olmsted County, Minnesota. We identified five genetic variants. None alter protein structure nor have apparent functional significance. Selected variants of sufficient frequency were tested for an association with course and severity of MS and one was tested for an association with susceptibility; none of the association tests were positive. Copyright (C) 2000 Elsevier Science B.V.
AB - Co-stimulation of T cells by B7-1, a protein that is expressed on antigen presenting cells, favors a T helper type1 (Th1) cellular response. Th1/Th2 bias may influence disease susceptibility or course of MS. We screened the entire coding sequence as well as the 5'- and 3'-untranslated regions of the B7-1 gene using a mutation scanning technique, dideoxyfingerprinting, in DNA from 111 patients with MS from Olmsted County, Minnesota. We identified five genetic variants. None alter protein structure nor have apparent functional significance. Selected variants of sufficient frequency were tested for an association with course and severity of MS and one was tested for an association with susceptibility; none of the association tests were positive. Copyright (C) 2000 Elsevier Science B.V.
KW - Association
KW - B7-1
KW - Genetics
KW - Multiple sclerosis
KW - Prognosis
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U2 - 10.1016/S0165-5728(00)00197-1
DO - 10.1016/S0165-5728(00)00197-1
M3 - Article
C2 - 10742561
AN - SCOPUS:0034717833
SN - 0165-5728
VL - 105
SP - 184
EP - 188
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 2
ER -