Genetic variation in the B7-1 gene in patients with multiple sclerosis

Brian G. Weinshenker, David D. Hebrink, Christopher Klein, Elizabeth J. Atkinson, Peter C. O'Brien, Cynthia T. McMurray

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Co-stimulation of T cells by B7-1, a protein that is expressed on antigen presenting cells, favors a T helper type1 (Th1) cellular response. Th1/Th2 bias may influence disease susceptibility or course of MS. We screened the entire coding sequence as well as the 5'- and 3'-untranslated regions of the B7-1 gene using a mutation scanning technique, dideoxyfingerprinting, in DNA from 111 patients with MS from Olmsted County, Minnesota. We identified five genetic variants. None alter protein structure nor have apparent functional significance. Selected variants of sufficient frequency were tested for an association with course and severity of MS and one was tested for an association with susceptibility; none of the association tests were positive. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)184-188
Number of pages5
JournalJournal of neuroimmunology
Volume105
Issue number2
DOIs
StatePublished - Jun 26 2000

Keywords

  • Association
  • B7-1
  • Genetics
  • Multiple sclerosis
  • Prognosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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