Abstract
We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel splice-junction sequence. We did not find an association between either this intronic variant or another common promoter variant and the course or severity of MS.
Original language | English (US) |
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Pages (from-to) | 1500-1503 |
Number of pages | 4 |
Journal | Neurology |
Volume | 52 |
Issue number | 7 |
DOIs | |
State | Published - Apr 22 1999 |
ASJC Scopus subject areas
- Clinical Neurology