Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS

Brian G. Weinshenker, D. Hebrink, D. M. Wingerchuk, C. J. Klein, E. Atkinson, P. C. O'Brien, C. T. McMurray

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel splice-junction sequence. We did not find an association between either this intronic variant or another common promoter variant and the course or severity of MS.

Original languageEnglish (US)
Pages (from-to)1500-1503
Number of pages4
JournalNeurology
Volume52
Issue number7
DOIs
StatePublished - Apr 22 1999

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS'. Together they form a unique fingerprint.

  • Cite this