Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS

Brian G. Weinshenker; D. Hebrink; D. M. Wingerchuk; C. J. Klein; E. Atkinson; P. C. O'Brien; C. T. McMurray

doi:10.1212/wnl.52.7.1500

Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS

Brian G. Weinshenker, D. Hebrink, D. M. Wingerchuk, C. J. Klein, E. Atkinson, P. C. O'Brien, C. T. McMurray

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel splice-junction sequence. We did not find an association between either this intronic variant or another common promoter variant and the course or severity of MS.

Original language	English (US)
Pages (from-to)	1500-1503
Number of pages	4
Journal	Neurology
Volume	52
Issue number	7
DOIs	https://doi.org/10.1212/wnl.52.7.1500
State	Published - Apr 22 1999

ASJC Scopus subject areas

Clinical Neurology

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abstract = "We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel splice-junction sequence. We did not find an association between either this intronic variant or another common promoter variant and the course or severity of MS.",

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AU - Klein, C. J.

AU - Atkinson, E.

AU - O'Brien, P. C.

AU - McMurray, C. T.

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AB - We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel splice-junction sequence. We did not find an association between either this intronic variant or another common promoter variant and the course or severity of MS.

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Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS

Abstract

ASJC Scopus subject areas

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