Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS

Brian G Weinshenker, D. Hebrink, Dean Marko Wingerchuk, Christopher Jon Klein, E. Atkinson, P. C. O'Brien, C. T. McMurray

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel splice-junction sequence. We did not find an association between either this intronic variant or another common promoter variant and the course or severity of MS.

Original languageEnglish (US)
Pages (from-to)1500-1503
Number of pages4
JournalNeurology
Volume52
Issue number7
StatePublished - Apr 22 1999

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Tumor Necrosis Factor Receptors
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

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Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS. / Weinshenker, Brian G; Hebrink, D.; Wingerchuk, Dean Marko; Klein, Christopher Jon; Atkinson, E.; O'Brien, P. C.; McMurray, C. T.

In: Neurology, Vol. 52, No. 7, 22.04.1999, p. 1500-1503.

Research output: Contribution to journalArticle

Weinshenker, BG, Hebrink, D, Wingerchuk, DM, Klein, CJ, Atkinson, E, O'Brien, PC & McMurray, CT 1999, 'Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS', Neurology, vol. 52, no. 7, pp. 1500-1503.
Weinshenker, Brian G ; Hebrink, D. ; Wingerchuk, Dean Marko ; Klein, Christopher Jon ; Atkinson, E. ; O'Brien, P. C. ; McMurray, C. T. / Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS. In: Neurology. 1999 ; Vol. 52, No. 7. pp. 1500-1503.
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