Abstract
DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1527-1531 |
| Number of pages | 5 |
| Journal | Leukemia Research |
| Volume | 37 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2013 |
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Keywords
- Autologous transplantation
- Base excision repair
- Disease progression
- Melphalan
- Multiple myeloma
- Nucleotide excision repair
- Single nucleotide polymorphisms
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients. / Thyagarajan, Bharat; Arora, Mukta; Guan, Weihua; Barcelo, Helene; Jackson, Scott; Kumar, Shaji K; Gertz, Morie.
In: Leukemia Research, Vol. 37, No. 11, 11.2013, p. 1527-1531.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients
AU - Thyagarajan, Bharat
AU - Arora, Mukta
AU - Guan, Weihua
AU - Barcelo, Helene
AU - Jackson, Scott
AU - Kumar, Shaji K
AU - Gertz, Morie
PY - 2013/11
Y1 - 2013/11
N2 - DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.
AB - DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.
KW - Autologous transplantation
KW - Base excision repair
KW - Disease progression
KW - Melphalan
KW - Multiple myeloma
KW - Nucleotide excision repair
KW - Single nucleotide polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=84886768796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886768796&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2013.07.012
DO - 10.1016/j.leukres.2013.07.012
M3 - Article
C2 - 24129343
AN - SCOPUS:84886768796
VL - 37
SP - 1527
EP - 1531
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 11
ER -