Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients

Bharat Thyagarajan; Mukta Arora; Weihua Guan; Helene Barcelo; Scott Jackson; Shaji Kumar; Morie Gertz

doi:10.1016/j.leukres.2013.07.012

Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients

Bharat Thyagarajan, Mukta Arora, Weihua Guan, Helene Barcelo, Scott Jackson, Shaji Kumar, Morie Gertz

Hematology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.

Original language	English (US)
Pages (from-to)	1527-1531
Number of pages	5
Journal	Leukemia Research
Volume	37
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2013.07.012
State	Published - Nov 2013

Keywords

Autologous transplantation
Base excision repair
Disease progression
Melphalan
Multiple myeloma
Nucleotide excision repair
Single nucleotide polymorphisms

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2013.07.012

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title = "Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients",

abstract = "DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.",

keywords = "Autologous transplantation, Base excision repair, Disease progression, Melphalan, Multiple myeloma, Nucleotide excision repair, Single nucleotide polymorphisms",

author = "Bharat Thyagarajan and Mukta Arora and Weihua Guan and Helene Barcelo and Scott Jackson and Shaji Kumar and Morie Gertz",

note = "Funding Information: This research study was supported by the American Cancer Society Institutional Research Grant ( IRG-58-001-49-IRG41 ) and funds from the W.W. Allen-Elsa U. Pardee Foundation Chair in Cancer Biology at the University of Minnesota. The study sponsors had no involvement in study design, collection, analysis, data interpretation, manuscript preparation and decision to submit the manuscript for publication. ",

year = "2013",

month = nov,

doi = "10.1016/j.leukres.2013.07.012",

language = "English (US)",

volume = "37",

pages = "1527--1531",

journal = "Leukemia Research",

issn = "0145-2126",

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T1 - Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients

AU - Thyagarajan, Bharat

AU - Arora, Mukta

AU - Guan, Weihua

AU - Barcelo, Helene

AU - Jackson, Scott

AU - Kumar, Shaji

AU - Gertz, Morie

N1 - Funding Information: This research study was supported by the American Cancer Society Institutional Research Grant ( IRG-58-001-49-IRG41 ) and funds from the W.W. Allen-Elsa U. Pardee Foundation Chair in Cancer Biology at the University of Minnesota. The study sponsors had no involvement in study design, collection, analysis, data interpretation, manuscript preparation and decision to submit the manuscript for publication.

PY - 2013/11

Y1 - 2013/11

N2 - DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.

AB - DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.

KW - Autologous transplantation

KW - Base excision repair

KW - Disease progression

KW - Melphalan

KW - Multiple myeloma

KW - Nucleotide excision repair

KW - Single nucleotide polymorphisms

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U2 - 10.1016/j.leukres.2013.07.012

DO - 10.1016/j.leukres.2013.07.012

M3 - Article

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AN - SCOPUS:84886768796

VL - 37

SP - 1527

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JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 11

ER -

Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients

Abstract

Keywords

ASJC Scopus subject areas

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