Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients

Bharat Thyagarajan; Mukta Arora; Weihua Guan; Helene Barcelo; Scott Jackson; Shaji Kumar; Morie Gertz

doi:10.1016/j.leukres.2013.07.012

Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients

Bharat Thyagarajan, Mukta Arora, Weihua Guan, Helene Barcelo, Scott Jackson, Shaji Kumar, Morie Gertz

Hematology

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.

Original language	English (US)
Pages (from-to)	1527-1531
Number of pages	5
Journal	Leukemia Research
Volume	37
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2013.07.012
State	Published - Nov 1 2013

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Keywords

Autologous transplantation
Base excision repair
Disease progression
Melphalan
Multiple myeloma
Nucleotide excision repair
Single nucleotide polymorphisms

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Cite this

Thyagarajan, B., Arora, M., Guan, W., Barcelo, H., Jackson, S., Kumar, S., & Gertz, M. (2013). Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients. Leukemia Research, 37(11), 1527-1531. https://doi.org/10.1016/j.leukres.2013.07.012

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abstract = "DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.",

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10.1016/j.leukres.2013.07.012