Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients

Bharat Thyagarajan, Mukta Arora, Weihua Guan, Helene Barcelo, Scott Jackson, Shaji K Kumar, Morie Gertz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.

Original languageEnglish (US)
Pages (from-to)1527-1531
Number of pages5
JournalLeukemia Research
Volume37
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Multiple Myeloma
DNA Repair
Disease Progression
Autologous Transplantation
Single Nucleotide Polymorphism
Melphalan
DNA Damage

Keywords

  • Autologous transplantation
  • Base excision repair
  • Disease progression
  • Melphalan
  • Multiple myeloma
  • Nucleotide excision repair
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients. / Thyagarajan, Bharat; Arora, Mukta; Guan, Weihua; Barcelo, Helene; Jackson, Scott; Kumar, Shaji K; Gertz, Morie.

In: Leukemia Research, Vol. 37, No. 11, 11.2013, p. 1527-1531.

Research output: Contribution to journalArticle

Thyagarajan, Bharat ; Arora, Mukta ; Guan, Weihua ; Barcelo, Helene ; Jackson, Scott ; Kumar, Shaji K ; Gertz, Morie. / Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients. In: Leukemia Research. 2013 ; Vol. 37, No. 11. pp. 1527-1531.
@article{2e7a09ea52a841d2a6e149b600111e00,
title = "Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients",
abstract = "DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.",
keywords = "Autologous transplantation, Base excision repair, Disease progression, Melphalan, Multiple myeloma, Nucleotide excision repair, Single nucleotide polymorphisms",
author = "Bharat Thyagarajan and Mukta Arora and Weihua Guan and Helene Barcelo and Scott Jackson and Kumar, {Shaji K} and Morie Gertz",
year = "2013",
month = "11",
doi = "10.1016/j.leukres.2013.07.012",
language = "English (US)",
volume = "37",
pages = "1527--1531",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients

AU - Thyagarajan, Bharat

AU - Arora, Mukta

AU - Guan, Weihua

AU - Barcelo, Helene

AU - Jackson, Scott

AU - Kumar, Shaji K

AU - Gertz, Morie

PY - 2013/11

Y1 - 2013/11

N2 - DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.

AB - DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p= 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.

KW - Autologous transplantation

KW - Base excision repair

KW - Disease progression

KW - Melphalan

KW - Multiple myeloma

KW - Nucleotide excision repair

KW - Single nucleotide polymorphisms

UR - http://www.scopus.com/inward/record.url?scp=84886768796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886768796&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2013.07.012

DO - 10.1016/j.leukres.2013.07.012

M3 - Article

C2 - 24129343

AN - SCOPUS:84886768796

VL - 37

SP - 1527

EP - 1531

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 11

ER -