Genetic to genomic vaccination

Stephen Albert Johnston, Michael A. Barry

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Our development of genetic immunization (unfortunately named 'DNA'- immunization at times) seems to have great promise as a vaccine delivery system. However, one is still left with the often formidable problem of discovering what gene of the pathogen to include in the genetic immunization vector. This is particularly a problem with pathogens with large genomes such as bacteria and parasites. We have developed a potential solution to this problem termed 'expression library immunization'. It involves using expression libraries in genetic immunization vectors to basically strip down the genome into protective genes. It may offer a systematic, unbiased approach to discover vaccine candidates.

Original languageEnglish (US)
Pages (from-to)808-809
Number of pages2
JournalVaccine
Volume15
Issue number8
DOIs
StatePublished - Jun 1 1997

Keywords

  • ELI
  • Expression library
  • Genome

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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