Genetic to genomic vaccination

Stephen Albert Johnston, Michael A Barry

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Our development of genetic immunization (unfortunately named 'DNA'- immunization at times) seems to have great promise as a vaccine delivery system. However, one is still left with the often formidable problem of discovering what gene of the pathogen to include in the genetic immunization vector. This is particularly a problem with pathogens with large genomes such as bacteria and parasites. We have developed a potential solution to this problem termed 'expression library immunization'. It involves using expression libraries in genetic immunization vectors to basically strip down the genome into protective genes. It may offer a systematic, unbiased approach to discover vaccine candidates.

Original languageEnglish (US)
Pages (from-to)808-809
Number of pages2
JournalVaccine
Volume15
Issue number8
DOIs
StatePublished - Jun 1997
Externally publishedYes

Fingerprint

Immunization
immunization
Vaccination
vaccination
genomics
Genetic Vectors
Vaccines
Genome
vaccines
genome
pathogens
Genes
Parasites
genes
Bacteria
parasites
DNA
bacteria

Keywords

  • ELI
  • Expression library
  • Genome

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Genetic to genomic vaccination. / Johnston, Stephen Albert; Barry, Michael A.

In: Vaccine, Vol. 15, No. 8, 06.1997, p. 808-809.

Research output: Contribution to journalArticle

Johnston, Stephen Albert ; Barry, Michael A. / Genetic to genomic vaccination. In: Vaccine. 1997 ; Vol. 15, No. 8. pp. 808-809.
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