Genetic testing for young-onset colorectal cancer: Case report and evidence-based clinical guidelines

Yaolin Zhou, Lisa Allyn Boardman, Robert Miller

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background. Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. Case report. We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of rectal cancer. Further clinical evaluation of the patient at our institution determined the cancer to be stage IIIA. The patient underwent genetic counseling and testing, which indicated he was negative for the most common familial cancer syndromes. After treatment with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy, the patient has done well. We review the hereditary cancer syndromes and genetic tests to consider for patients with early-onset colorectal cancer. Conclusions. This case underscores the importance of following cancer-screening guidelines.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalRadiology and Oncology
Volume44
Issue number1
DOIs
StatePublished - Mar 1 2010

Fingerprint

Genetic Testing
Colorectal Neoplasms
Guidelines
Hereditary Neoplastic Syndromes
Hereditary Nonpolyposis Colorectal Neoplasms
Adenomatous Polyposis Coli
Neoadjuvant Therapy
Gastrointestinal Hemorrhage
Genetic Counseling
Chemoradiotherapy
Adjuvant Chemotherapy
Rectal Neoplasms
Polyps
Early Detection of Cancer
Neoplasms
Colon

Keywords

  • Adenomatous polyposis coli
  • Attenuated familial adenomatous polyposis
  • Colorectal cancer
  • Familial adenomatous polyposis
  • Microsatellite instability
  • MYH-associated polyposis

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Genetic testing for young-onset colorectal cancer : Case report and evidence-based clinical guidelines. / Zhou, Yaolin; Boardman, Lisa Allyn; Miller, Robert.

In: Radiology and Oncology, Vol. 44, No. 1, 01.03.2010, p. 57-61.

Research output: Contribution to journalArticle

@article{ff8eae8d719343b8b04fcdc3ec4a8bc8,
title = "Genetic testing for young-onset colorectal cancer: Case report and evidence-based clinical guidelines",
abstract = "Background. Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. Case report. We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of rectal cancer. Further clinical evaluation of the patient at our institution determined the cancer to be stage IIIA. The patient underwent genetic counseling and testing, which indicated he was negative for the most common familial cancer syndromes. After treatment with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy, the patient has done well. We review the hereditary cancer syndromes and genetic tests to consider for patients with early-onset colorectal cancer. Conclusions. This case underscores the importance of following cancer-screening guidelines.",
keywords = "Adenomatous polyposis coli, Attenuated familial adenomatous polyposis, Colorectal cancer, Familial adenomatous polyposis, Microsatellite instability, MYH-associated polyposis",
author = "Yaolin Zhou and Boardman, {Lisa Allyn} and Robert Miller",
year = "2010",
month = "3",
day = "1",
doi = "10.2478/v10019-010-0005-0",
language = "English (US)",
volume = "44",
pages = "57--61",
journal = "Radiology and Oncology",
issn = "1318-2099",
publisher = "Slovenian Medical Society / Croatian Medical Association",
number = "1",

}

TY - JOUR

T1 - Genetic testing for young-onset colorectal cancer

T2 - Case report and evidence-based clinical guidelines

AU - Zhou, Yaolin

AU - Boardman, Lisa Allyn

AU - Miller, Robert

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Background. Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. Case report. We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of rectal cancer. Further clinical evaluation of the patient at our institution determined the cancer to be stage IIIA. The patient underwent genetic counseling and testing, which indicated he was negative for the most common familial cancer syndromes. After treatment with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy, the patient has done well. We review the hereditary cancer syndromes and genetic tests to consider for patients with early-onset colorectal cancer. Conclusions. This case underscores the importance of following cancer-screening guidelines.

AB - Background. Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. Case report. We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of rectal cancer. Further clinical evaluation of the patient at our institution determined the cancer to be stage IIIA. The patient underwent genetic counseling and testing, which indicated he was negative for the most common familial cancer syndromes. After treatment with neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy, the patient has done well. We review the hereditary cancer syndromes and genetic tests to consider for patients with early-onset colorectal cancer. Conclusions. This case underscores the importance of following cancer-screening guidelines.

KW - Adenomatous polyposis coli

KW - Attenuated familial adenomatous polyposis

KW - Colorectal cancer

KW - Familial adenomatous polyposis

KW - Microsatellite instability

KW - MYH-associated polyposis

UR - http://www.scopus.com/inward/record.url?scp=77950153978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950153978&partnerID=8YFLogxK

U2 - 10.2478/v10019-010-0005-0

DO - 10.2478/v10019-010-0005-0

M3 - Article

C2 - 22933892

AN - SCOPUS:77950153978

VL - 44

SP - 57

EP - 61

JO - Radiology and Oncology

JF - Radiology and Oncology

SN - 1318-2099

IS - 1

ER -