Genetic susceptibility to ischemic stroke

James F Meschia, Bradford B. Worrall, Stephen S. Rich

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Clinicians who treat patients with stroke need to be aware of several single-gene disorders that have ischemic stroke as a major feature, including sickle cell disease, Fabry disease, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, and retinal vasculopathy with cerebral leukodystrophy. The reported genome-wide association studies of ischemic stroke and several related phenotypes (for example, ischemic white matter disease) have shown that no single common genetic variant imparts major risk. Larger studies with samples numbering in the thousands are ongoing to identify common variants with smaller effects on risk. Pharmacogenomic studies have uncovered genetic determinants of response to warfarin, statins and clopidogrel. Despite increasing knowledge of stroke genetics, incorporating this new knowledge into clinical practice remains a challenge. The goals of this article are to review common single-gene disorders relevant to ischemic stroke, summarize the status of candidate gene and genome-wide studies aimed at discovering genetic stroke risk factors, and to briefly discuss pharmacogenomics related to stroke treatment.

Original languageEnglish (US)
Pages (from-to)369-378
Number of pages10
JournalNature Reviews Neurology
Volume7
Issue number7
DOIs
StatePublished - Jul 2011

Fingerprint

Genetic Predisposition to Disease
Stroke
clopidogrel
CADASIL
Genes
Fabry Disease
Leukoencephalopathies
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Genome-Wide Association Study
Pharmacogenetics
Sickle Cell Anemia
Warfarin
Genome
Phenotype

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Genetic susceptibility to ischemic stroke. / Meschia, James F; Worrall, Bradford B.; Rich, Stephen S.

In: Nature Reviews Neurology, Vol. 7, No. 7, 07.2011, p. 369-378.

Research output: Contribution to journalArticle

Meschia, James F ; Worrall, Bradford B. ; Rich, Stephen S. / Genetic susceptibility to ischemic stroke. In: Nature Reviews Neurology. 2011 ; Vol. 7, No. 7. pp. 369-378.
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