TY - JOUR
T1 - Genetic susceptibility to diffuse large B-cell lymphoma in a pooled study of three Eastern Asian populations
AU - Bassig, Bryan A.
AU - Cerhan, James R.
AU - Au, Wing Yan
AU - Kim, Hee Nam
AU - Sangrajrang, Suleeporn
AU - Hu, Wei
AU - Tse, Jovic
AU - Berndt, Sonja
AU - Zheng, Tongzhang
AU - Zhang, Heping
AU - Pornsopone, Pattarapong
AU - Lee, Je Jung
AU - Kim, Hyeoung Joon
AU - Skibola, Christine F.
AU - Vijai, Joseph
AU - Burdette, Laurie
AU - Yeager, Meredith
AU - Brennan, Paul
AU - Shin, Min Ho
AU - Liang, Raymond
AU - Chanock, Stephen
AU - Lan, Qing
AU - Rothman, Nathaniel
N1 - Publisher Copyright:
© 2015 John Wiley & Sons A/S.
PY - 2015/11
Y1 - 2015/11
N2 - Objectives: Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma (NHL) and is the most common NHL subtype diagnosed worldwide. The first large-scale genome-wide association study (GWAS) of DLBCL with over 4000 cases conducted among individuals of European ancestry recently identified five independent SNPs that achieved genome-wide significance, and two SNPs that showed a suggestive association with DLBCL risk. Methods: To evaluate whether Eastern Asians and individuals of European ancestry share similar genetic risk factors for this disease, we attempted to replicate these GWAS findings in a pooled series of 1124 DLBCL cases and 3596 controls from Hong Kong, South Korea, and Thailand. Results: Three of the five genome-wide significant SNPs from the DLBCL GWAS were significantly associated with DLBCL in our study population, including the top finding from the GWAS, EXOC2 rs116446171, which achieved genome-wide significance in our data (per allele OR = 2.04, 95% CI = 1.63-2.56; ptrend = 3.9 × 10-10). Additionally, we observed a significant association with PVT1 rs13255292 (per allele OR = 1.34, 95% CI = 1.19-1.52; ptrend = 2.1 × 10-6), which was the second strongest finding in the GWAS, and with HLA-B rs2523607 (per allele OR = 3.05, 95% CI = 1.32-7.05; ptrend = 0.009). Conclusions: Our study, which provides the first evaluation in Eastern Asians of SNPs definitively associated with DLBCL risk in individuals of European ancestry, indicates that at least some of the genetic factors associated with risk of DLBCL are similar between these populations.
AB - Objectives: Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma (NHL) and is the most common NHL subtype diagnosed worldwide. The first large-scale genome-wide association study (GWAS) of DLBCL with over 4000 cases conducted among individuals of European ancestry recently identified five independent SNPs that achieved genome-wide significance, and two SNPs that showed a suggestive association with DLBCL risk. Methods: To evaluate whether Eastern Asians and individuals of European ancestry share similar genetic risk factors for this disease, we attempted to replicate these GWAS findings in a pooled series of 1124 DLBCL cases and 3596 controls from Hong Kong, South Korea, and Thailand. Results: Three of the five genome-wide significant SNPs from the DLBCL GWAS were significantly associated with DLBCL in our study population, including the top finding from the GWAS, EXOC2 rs116446171, which achieved genome-wide significance in our data (per allele OR = 2.04, 95% CI = 1.63-2.56; ptrend = 3.9 × 10-10). Additionally, we observed a significant association with PVT1 rs13255292 (per allele OR = 1.34, 95% CI = 1.19-1.52; ptrend = 2.1 × 10-6), which was the second strongest finding in the GWAS, and with HLA-B rs2523607 (per allele OR = 3.05, 95% CI = 1.32-7.05; ptrend = 0.009). Conclusions: Our study, which provides the first evaluation in Eastern Asians of SNPs definitively associated with DLBCL risk in individuals of European ancestry, indicates that at least some of the genetic factors associated with risk of DLBCL are similar between these populations.
KW - Diffuse large B-cell lymphoma
KW - Eastern asians
KW - Genetic susceptibility to DLBCL
KW - Lymphoma
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U2 - 10.1111/ejh.12513
DO - 10.1111/ejh.12513
M3 - Article
C2 - 25611436
AN - SCOPUS:84944513280
SN - 0902-4441
VL - 95
SP - 442
EP - 448
JO - European Journal of Haematology
JF - European Journal of Haematology
IS - 5
ER -