Genetic studies of the mouse mutations mahogany and mahoganoid

K. A. Miller, T. M. Gunn, Minerva M Carrasquillo, M. L. Lamoreux, D. B. Galbraith, G. S. Barsh

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

The mouse mutations mahogany (mg) and mahoganoid (md) are negative modifiers of the Agouti coat color gene, which encodes a paracrine signaling molecule that induces a switch in melanin synthesis from eumelanin to pheomelanin. Animals mutant for md or mg synthesize very little or no pheomelanin depending on Agouti gene background. The Agouti protein is normally expressed in the skin and acts as an antagonist of the melanocyte receptor for α-MSH (Mc1r); however, ectopic expression of Agouti causes obesity, possibly by antagonizing melanocortin receptors expressed in the brain. To investigate where md and mg lie in a genetic pathway with rcgard to Agouti and Mc1r signaling, we determined the effects of these mutations in animals that carried either a loss-of-function Mc1r mutation (recessive yellow, Mc1r) or a gain-of-function Agouti mutation (lethal yellow, A(y)). We found that the Mc1r mutation suppressed the effects of rod and mg, but that md and mg suppressed the effects of A(y) on both coat color and obesity. Plasma levels of α-MSH and of ACTH were unaffccted by md or mg. These results suggest that md and mg interfere directly with Agouti signaling, possibly at the level of protein production or receptor regulation.

Original languageEnglish (US)
Pages (from-to)1407-1415
Number of pages9
JournalGenetics
Volume146
Issue number4
StatePublished - 1997
Externally publishedYes

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Mutation
Agouti Signaling Protein
Color
Obesity
Melanocortin Receptors
Paracrine Communication
Melanocyte-Stimulating Hormones
Melanocytes
Melanins
Adrenocorticotropic Hormone
Genes
Dasyproctidae
Skin
Brain
Proteins
pheomelanin

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Miller, K. A., Gunn, T. M., Carrasquillo, M. M., Lamoreux, M. L., Galbraith, D. B., & Barsh, G. S. (1997). Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics, 146(4), 1407-1415.

Genetic studies of the mouse mutations mahogany and mahoganoid. / Miller, K. A.; Gunn, T. M.; Carrasquillo, Minerva M; Lamoreux, M. L.; Galbraith, D. B.; Barsh, G. S.

In: Genetics, Vol. 146, No. 4, 1997, p. 1407-1415.

Research output: Contribution to journalArticle

Miller, KA, Gunn, TM, Carrasquillo, MM, Lamoreux, ML, Galbraith, DB & Barsh, GS 1997, 'Genetic studies of the mouse mutations mahogany and mahoganoid', Genetics, vol. 146, no. 4, pp. 1407-1415.
Miller KA, Gunn TM, Carrasquillo MM, Lamoreux ML, Galbraith DB, Barsh GS. Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics. 1997;146(4):1407-1415.
Miller, K. A. ; Gunn, T. M. ; Carrasquillo, Minerva M ; Lamoreux, M. L. ; Galbraith, D. B. ; Barsh, G. S. / Genetic studies of the mouse mutations mahogany and mahoganoid. In: Genetics. 1997 ; Vol. 146, No. 4. pp. 1407-1415.
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