Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation

Hong Chang, X. Y. Qi, S. Samiee, Q. L. Yi, C. Chen, S. Trudel, Joseph R Mikhael, D. Reece, Alexander Keith Stewart

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Genetic aberrations have emerged as major prognostic factors for patients with multiple myeloma (MM). We evaluated 126 MM patients for t(4;14) or t(11;14), 13q or p53 deletions and correlated the number of genetic aberrations with patient's clinical outcome following undergoing autologous stem cell transplantation. We demonstrate the significance of genetic-based risk classification that clearly segregate patients into low (no genetic abnormalities or only t(11;14)), intermediate (any one of the genetic abnormalities other than t(11;14)) and high-risk groups (any two or more of the genetic abnormalities other than t(11;14)). High-risk patients do not benefit from stem cell transplant and should be offered alternative therapies.

Original languageEnglish (US)
Pages (from-to)793-796
Number of pages4
JournalBone Marrow Transplantation
Volume36
Issue number9
DOIs
StatePublished - Nov 2005
Externally publishedYes

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Stem Cell Transplantation
Multiple Myeloma
Complementary Therapies
Stem Cells
Transplants

Keywords

  • 13q deletions
  • Autologous stem cell transplantation
  • Fluorescence in situ hybridization
  • IgH translocations
  • Multiple myeloma
  • p53 deletions

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation. / Chang, Hong; Qi, X. Y.; Samiee, S.; Yi, Q. L.; Chen, C.; Trudel, S.; Mikhael, Joseph R; Reece, D.; Stewart, Alexander Keith.

In: Bone Marrow Transplantation, Vol. 36, No. 9, 11.2005, p. 793-796.

Research output: Contribution to journalArticle

Chang, Hong ; Qi, X. Y. ; Samiee, S. ; Yi, Q. L. ; Chen, C. ; Trudel, S. ; Mikhael, Joseph R ; Reece, D. ; Stewart, Alexander Keith. / Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation. In: Bone Marrow Transplantation. 2005 ; Vol. 36, No. 9. pp. 793-796.
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AU - Qi, X. Y.

AU - Samiee, S.

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AU - Chen, C.

AU - Trudel, S.

AU - Mikhael, Joseph R

AU - Reece, D.

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