Genetic Predisposition to Autoimmune Diseases Conferred by the Major Histocompatibility Complex: Utility of Animal Models

Veena Taneja, Ashutosh Mangalam, Chella S. David

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The human immune system has evolved over the centuries due to strong selection pressures caused by various infectious agents. The major players for clearing infection are the genes of major histocompatibility complex (MHC). The MHC region encodes for the most polymorphic genes in the human genome, the human leukocyte antigen (HLA) genes. A population with diverse HLA class II alleles is able to generate a response to various infections and thereby has a survival advantage. However, the presence of certain class II alleles has been linked to the development of autoimmune diseases. The development of autoimmune diseases, such as rheumatoid arthritis (RA), type 1 diabetes (T1D), multiple sclerosis (MS), or celiac disease (CD) or others is determined by genetic and environmental factors. Among the genetic factors, HLA class II genes confer the highest relative risk for the majority of autoimmune diseases. Thus autoimmunity is a side effect of an HLA gene which is efficient in clearing infections.

Original languageEnglish (US)
Title of host publicationThe Autoimmune Diseases
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
Pages365-380
Number of pages16
ISBN (Print)9780123849298
DOIs
StatePublished - Dec 1 2013

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Keywords

  • Autoimmune diseases
  • Collagen-induced arthritis
  • Deamidation
  • Deimination
  • Environmental factors
  • Experimental autoimmune encephalomyelitis
  • Human leukocyte antigens
  • Infectious agents
  • Transgenic/knockout mice

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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