Genetic polymorphisms in southwest alaskan eskimos

Gloria M. Petersen; Joel I. Ward; Paul I. Terasaki; Moses S. Schanfiel; Robert E. Ferrell; Edward M. Scott; Min S. Park

doi:10.1159/000154008

Genetic polymorphisms in southwest alaskan eskimos

Gloria M. Petersen, Joel I. Ward, Paul I. Terasaki, Moses S. Schanfiel, Robert E. Ferrell, Edward M. Scott, Min S. Park

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Allele frequencies of 28 genelic loci were determined in subsets (n ranged from 52 to 698) of a sample of Yupik-speaking Eskimos from southwestern Alaska. Five loci were monomorphic (KellKp(b+), ADA¹, AK¹, HB^A, and PGD^A). At the other loci, the most frequent alleles were ABO⁰ (0.580), Fy^a (0.960), Jk^b (0.513), Ms (0.333), CDe (0.591), ACP^A (0.566), ESD¹ (0.890), GLO² (0.736), GPT₁, (0.653), Hp² (0.654), PGM₁, (0.836), PGP₁, (0.972), and UMPK¹ (0.873). The most frequent immunoglobulin allotypeGm(l;21) occurred with a frequency of 0.829. The HLA alleles that occurred with highest frequencies were A24 (0.626), Bw48 (0.184), Cw3 (0.404), and DR4 (0.329). The average heterozygosity at all loci was 0.423. Based on the presence of the European allotype, Gm^{3;23;5, 11, 13}the proportion of European admixture in the Eskimo population was estimated to be 2.1%.

Original language	English (US)
Pages (from-to)	236-247
Number of pages	12
Journal	Human Heredity
Volume	41
Issue number	4
DOIs	https://doi.org/10.1159/000154008
State	Published - 1991

Keywords

Admixture
Eskimo
Genetic polymorphisms
Human lymphocyte antigens
Immunoglobulins

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1159/000154008

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title = "Genetic polymorphisms in southwest alaskan eskimos",

abstract = "Allele frequencies of 28 genelic loci were determined in subsets (n ranged from 52 to 698) of a sample of Yupik-speaking Eskimos from southwestern Alaska. Five loci were monomorphic (KellKp(b+), ADA1, AK1, HBA, and PGDA). At the other loci, the most frequent alleles were ABO0 (0.580), Fya (0.960), Jkb (0.513), Ms (0.333), CDe (0.591), ACPA (0.566), ESD1 (0.890), GLO2 (0.736), GPT1, (0.653), Hp2 (0.654), PGM1, (0.836), PGP1, (0.972), and UMPK1 (0.873). The most frequent immunoglobulin allotypeGm(l;21) occurred with a frequency of 0.829. The HLA alleles that occurred with highest frequencies were A24 (0.626), Bw48 (0.184), Cw3 (0.404), and DR4 (0.329). The average heterozygosity at all loci was 0.423. Based on the presence of the European allotype, Gm3;23;5, 11, 13the proportion of European admixture in the Eskimo population was estimated to be 2.1%.",

keywords = "Admixture, Eskimo, Genetic polymorphisms, Human lymphocyte antigens, Immunoglobulins",

author = "Petersen, {Gloria M.} and Ward, {Joel I.} and Terasaki, {Paul I.} and Schanfiel, {Moses S.} and Ferrell, {Robert E.} and Scott, {Edward M.} and Park, {Min S.}",

year = "1991",

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T1 - Genetic polymorphisms in southwest alaskan eskimos

AU - Petersen, Gloria M.

AU - Ward, Joel I.

AU - Terasaki, Paul I.

AU - Schanfiel, Moses S.

AU - Ferrell, Robert E.

AU - Scott, Edward M.

AU - Park, Min S.

PY - 1991

Y1 - 1991

N2 - Allele frequencies of 28 genelic loci were determined in subsets (n ranged from 52 to 698) of a sample of Yupik-speaking Eskimos from southwestern Alaska. Five loci were monomorphic (KellKp(b+), ADA1, AK1, HBA, and PGDA). At the other loci, the most frequent alleles were ABO0 (0.580), Fya (0.960), Jkb (0.513), Ms (0.333), CDe (0.591), ACPA (0.566), ESD1 (0.890), GLO2 (0.736), GPT1, (0.653), Hp2 (0.654), PGM1, (0.836), PGP1, (0.972), and UMPK1 (0.873). The most frequent immunoglobulin allotypeGm(l;21) occurred with a frequency of 0.829. The HLA alleles that occurred with highest frequencies were A24 (0.626), Bw48 (0.184), Cw3 (0.404), and DR4 (0.329). The average heterozygosity at all loci was 0.423. Based on the presence of the European allotype, Gm3;23;5, 11, 13the proportion of European admixture in the Eskimo population was estimated to be 2.1%.

AB - Allele frequencies of 28 genelic loci were determined in subsets (n ranged from 52 to 698) of a sample of Yupik-speaking Eskimos from southwestern Alaska. Five loci were monomorphic (KellKp(b+), ADA1, AK1, HBA, and PGDA). At the other loci, the most frequent alleles were ABO0 (0.580), Fya (0.960), Jkb (0.513), Ms (0.333), CDe (0.591), ACPA (0.566), ESD1 (0.890), GLO2 (0.736), GPT1, (0.653), Hp2 (0.654), PGM1, (0.836), PGP1, (0.972), and UMPK1 (0.873). The most frequent immunoglobulin allotypeGm(l;21) occurred with a frequency of 0.829. The HLA alleles that occurred with highest frequencies were A24 (0.626), Bw48 (0.184), Cw3 (0.404), and DR4 (0.329). The average heterozygosity at all loci was 0.423. Based on the presence of the European allotype, Gm3;23;5, 11, 13the proportion of European admixture in the Eskimo population was estimated to be 2.1%.

KW - Admixture

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KW - Genetic polymorphisms

KW - Human lymphocyte antigens

KW - Immunoglobulins

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Genetic polymorphisms in southwest alaskan eskimos

Abstract

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