Genetic modification of cerebral arterial wall: Implications for prevention and treatment of cerebral vasospasm

Anantha Vijay, R. Santhanam, Zvonimir S. Katusic

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Genetic modification of cerebral vessels represents a promising and novel approach for prevention and/or treatment of various cerebral vascular disorders, including cerebral vasospasm. In this review, we focus on the current understanding of the use of gene transfer to the cerebral arteries for prevention and/or treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). We also discuss the recent developments in vascular therapeutics, involving the autologous use of progenitor cells for repair of damaged vessels, as well as a cell-based gene delivery approach for the prevention and treatment of cerebral vasospasm.

Original languageEnglish (US)
Pages (from-to)759-768
Number of pages10
JournalNeurological research
Volume28
Issue number7
DOIs
StatePublished - Oct 1 2006

Keywords

  • Adenovirus
  • Endothelial nitric oxide synthase
  • Progenitor cells
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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