TY - JOUR
T1 - Genetic modification of cerebral arterial wall
T2 - Implications for prevention and treatment of cerebral vasospasm
AU - Vijay, Anantha
AU - Santhanam, R.
AU - Katusic, Zvonimir S.
PY - 2006/10
Y1 - 2006/10
N2 - Genetic modification of cerebral vessels represents a promising and novel approach for prevention and/or treatment of various cerebral vascular disorders, including cerebral vasospasm. In this review, we focus on the current understanding of the use of gene transfer to the cerebral arteries for prevention and/or treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). We also discuss the recent developments in vascular therapeutics, involving the autologous use of progenitor cells for repair of damaged vessels, as well as a cell-based gene delivery approach for the prevention and treatment of cerebral vasospasm.
AB - Genetic modification of cerebral vessels represents a promising and novel approach for prevention and/or treatment of various cerebral vascular disorders, including cerebral vasospasm. In this review, we focus on the current understanding of the use of gene transfer to the cerebral arteries for prevention and/or treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). We also discuss the recent developments in vascular therapeutics, involving the autologous use of progenitor cells for repair of damaged vessels, as well as a cell-based gene delivery approach for the prevention and treatment of cerebral vasospasm.
KW - Adenovirus
KW - Endothelial nitric oxide synthase
KW - Progenitor cells
KW - Subarachnoid hemorrhage
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U2 - 10.1179/016164106X152034
DO - 10.1179/016164106X152034
M3 - Review article
C2 - 17164039
AN - SCOPUS:33750458365
SN - 0161-6412
VL - 28
SP - 759
EP - 768
JO - Neurological research
JF - Neurological research
IS - 7
ER -