Genetic marker family studies in familial Mediterranean fever (FMF) in Armenians

T. Shohat, G. M. Petersen, R. S. Sparkes, D. Langfield, J. Bickal, J. R. Korenberg, A. D. Schwabe, J. I. Rotter

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Familial Mediterranean fever is an autosomal recessive disease manifested by recurrent short episodes of fever associated with polyserositis. It is common in a variety of Mediterranean and near Eastern populations. The biochemical defect is unknown, and there have been few studies of genetic marker associations or linkage with the disease. We have screened blood samples from members of 14 nuclear Armenian families, the population with the highest known gene frequency, for 19 different polymorphic phenotypic genetic markers. These 14 families included 31 affected and 43 unaffected family members. No association was found with any of the markers studied. Linkage could be excluded at the distance of 0–15% recombination with 14 markers. Linkage could not be excluded with 5 other markers. These results exclude the FMF gene from those portions of the human gene map that are at least 0.5% recombination distance from these 14 genetic markers, and represent the first comprehensive step in the eventual localization and isolation of the FMF gene.

Original languageEnglish (US)
Pages (from-to)332-339
Number of pages8
JournalClinical Genetics
Volume38
Issue number5
DOIs
StatePublished - Nov 1990

Keywords

  • association
  • familial Mediterranean fever
  • genetic linkage
  • genetic markers

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Shohat, T., Petersen, G. M., Sparkes, R. S., Langfield, D., Bickal, J., Korenberg, J. R., Schwabe, A. D., & Rotter, J. I. (1990). Genetic marker family studies in familial Mediterranean fever (FMF) in Armenians. Clinical Genetics, 38(5), 332-339. https://doi.org/10.1111/j.1399-0004.1990.tb03591.x