Genetic marker family studies in familial Mediterranean fever (FMF) in Armenians

T. Shohat, Gloria M Petersen, G. M. Petersen, R. S. Sparkes, D. Langfield, J. Bickal, J. R. Korenberg, A. D. Schwabe, J. I. Rotter

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Familial Mediterranean fever is an autosomal recessive disease manifested by recurrent short episodes of fever associated with polyserositis. It is common in a variety of Mediterranean and near Eastern populations. The biochemical defect is unknown, and there have been few studies of genetic marker associations or linkage with the disease. We have screened blood samples from members of 14 nuclear Armenian families, the population with the highest known gene frequency, for 19 different polymorphic phenotypic genetic markers. These 14 families included 31 affected and 43 unaffected family members. No association was found with any of the markers studied. Linkage could be excluded at the distance of 0-15% recombination with 14 markers. Linkage could not be excluded with 5 other markers. These results exclude the FMF gene from those portions of the human gene map that are at least 0.5% recombination distance from these 14 genetic markers, and represent the first comprehensive step in the eventual localization and isolation of the FMF gene.

Original languageEnglish (US)
Pages (from-to)332-339
Number of pages8
JournalClinical Genetics
Volume38
Issue number5
StatePublished - 1990
Externally publishedYes

Fingerprint

Familial Mediterranean Fever
Genetic Markers
Genetic Recombination
Genes
Genetic Linkage
Nuclear Family
Gene Frequency
Population
Fever

Keywords

  • Association
  • Familial Mediterranean fever
  • Genetic linkage
  • Genetic markers

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Shohat, T., Petersen, G. M., Petersen, G. M., Sparkes, R. S., Langfield, D., Bickal, J., ... Rotter, J. I. (1990). Genetic marker family studies in familial Mediterranean fever (FMF) in Armenians. Clinical Genetics, 38(5), 332-339.

Genetic marker family studies in familial Mediterranean fever (FMF) in Armenians. / Shohat, T.; Petersen, Gloria M; Petersen, G. M.; Sparkes, R. S.; Langfield, D.; Bickal, J.; Korenberg, J. R.; Schwabe, A. D.; Rotter, J. I.

In: Clinical Genetics, Vol. 38, No. 5, 1990, p. 332-339.

Research output: Contribution to journalArticle

Shohat, T, Petersen, GM, Petersen, GM, Sparkes, RS, Langfield, D, Bickal, J, Korenberg, JR, Schwabe, AD & Rotter, JI 1990, 'Genetic marker family studies in familial Mediterranean fever (FMF) in Armenians', Clinical Genetics, vol. 38, no. 5, pp. 332-339.
Shohat T, Petersen GM, Petersen GM, Sparkes RS, Langfield D, Bickal J et al. Genetic marker family studies in familial Mediterranean fever (FMF) in Armenians. Clinical Genetics. 1990;38(5):332-339.
Shohat, T. ; Petersen, Gloria M ; Petersen, G. M. ; Sparkes, R. S. ; Langfield, D. ; Bickal, J. ; Korenberg, J. R. ; Schwabe, A. D. ; Rotter, J. I. / Genetic marker family studies in familial Mediterranean fever (FMF) in Armenians. In: Clinical Genetics. 1990 ; Vol. 38, No. 5. pp. 332-339.
@article{b112ed5029384cf2b823b23209161b17,
title = "Genetic marker family studies in familial Mediterranean fever (FMF) in Armenians",
abstract = "Familial Mediterranean fever is an autosomal recessive disease manifested by recurrent short episodes of fever associated with polyserositis. It is common in a variety of Mediterranean and near Eastern populations. The biochemical defect is unknown, and there have been few studies of genetic marker associations or linkage with the disease. We have screened blood samples from members of 14 nuclear Armenian families, the population with the highest known gene frequency, for 19 different polymorphic phenotypic genetic markers. These 14 families included 31 affected and 43 unaffected family members. No association was found with any of the markers studied. Linkage could be excluded at the distance of 0-15{\%} recombination with 14 markers. Linkage could not be excluded with 5 other markers. These results exclude the FMF gene from those portions of the human gene map that are at least 0.5{\%} recombination distance from these 14 genetic markers, and represent the first comprehensive step in the eventual localization and isolation of the FMF gene.",
keywords = "Association, Familial Mediterranean fever, Genetic linkage, Genetic markers",
author = "T. Shohat and Petersen, {Gloria M} and Petersen, {G. M.} and Sparkes, {R. S.} and D. Langfield and J. Bickal and Korenberg, {J. R.} and Schwabe, {A. D.} and Rotter, {J. I.}",
year = "1990",
language = "English (US)",
volume = "38",
pages = "332--339",
journal = "Clinical Genetics",
issn = "0009-9163",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Genetic marker family studies in familial Mediterranean fever (FMF) in Armenians

AU - Shohat, T.

AU - Petersen, Gloria M

AU - Petersen, G. M.

AU - Sparkes, R. S.

AU - Langfield, D.

AU - Bickal, J.

AU - Korenberg, J. R.

AU - Schwabe, A. D.

AU - Rotter, J. I.

PY - 1990

Y1 - 1990

N2 - Familial Mediterranean fever is an autosomal recessive disease manifested by recurrent short episodes of fever associated with polyserositis. It is common in a variety of Mediterranean and near Eastern populations. The biochemical defect is unknown, and there have been few studies of genetic marker associations or linkage with the disease. We have screened blood samples from members of 14 nuclear Armenian families, the population with the highest known gene frequency, for 19 different polymorphic phenotypic genetic markers. These 14 families included 31 affected and 43 unaffected family members. No association was found with any of the markers studied. Linkage could be excluded at the distance of 0-15% recombination with 14 markers. Linkage could not be excluded with 5 other markers. These results exclude the FMF gene from those portions of the human gene map that are at least 0.5% recombination distance from these 14 genetic markers, and represent the first comprehensive step in the eventual localization and isolation of the FMF gene.

AB - Familial Mediterranean fever is an autosomal recessive disease manifested by recurrent short episodes of fever associated with polyserositis. It is common in a variety of Mediterranean and near Eastern populations. The biochemical defect is unknown, and there have been few studies of genetic marker associations or linkage with the disease. We have screened blood samples from members of 14 nuclear Armenian families, the population with the highest known gene frequency, for 19 different polymorphic phenotypic genetic markers. These 14 families included 31 affected and 43 unaffected family members. No association was found with any of the markers studied. Linkage could be excluded at the distance of 0-15% recombination with 14 markers. Linkage could not be excluded with 5 other markers. These results exclude the FMF gene from those portions of the human gene map that are at least 0.5% recombination distance from these 14 genetic markers, and represent the first comprehensive step in the eventual localization and isolation of the FMF gene.

KW - Association

KW - Familial Mediterranean fever

KW - Genetic linkage

KW - Genetic markers

UR - http://www.scopus.com/inward/record.url?scp=0025083708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025083708&partnerID=8YFLogxK

M3 - Article

C2 - 2282713

AN - SCOPUS:0025083708

VL - 38

SP - 332

EP - 339

JO - Clinical Genetics

JF - Clinical Genetics

SN - 0009-9163

IS - 5

ER -