Abstract
Our understanding of the pathophysiology of the majority of common psychiatric disorders is limited, and in most cases the evidence for genetic risk factors remains our strongest clue to their cause. Their precise genetic architecture is however largely unknown but is likely to be complex, with the phenotype being a result of interactions between multiple genetic and environmental factors. Consequently each DNA variant will inevitably have a modest effect on disease risk. In this review we will provide a general outline to the main approaches that are used in studies aiming to identify susceptibility genes for psychiatric disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 22-26 |
| Number of pages | 5 |
| Journal | Psychiatry |
| Volume | 4 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2005 |
| Externally published | Yes |
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Keywords
- association
- basic sciences
- complex traits
- genetic mapping
- linkage
- neuropsychiatry
- whole genome
ASJC Scopus subject areas
- Psychiatry and Mental health
- Phychiatric Mental Health
Cite this
Genetic mapping approaches in neuropsychiatry. / Norton, Nadine; Dwyer, Sarah; O'Donovan, Michael C.; Williams, Nigel M.
In: Psychiatry, Vol. 4, No. 12, 01.12.2005, p. 22-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic mapping approaches in neuropsychiatry
AU - Norton, Nadine
AU - Dwyer, Sarah
AU - O'Donovan, Michael C.
AU - Williams, Nigel M.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Our understanding of the pathophysiology of the majority of common psychiatric disorders is limited, and in most cases the evidence for genetic risk factors remains our strongest clue to their cause. Their precise genetic architecture is however largely unknown but is likely to be complex, with the phenotype being a result of interactions between multiple genetic and environmental factors. Consequently each DNA variant will inevitably have a modest effect on disease risk. In this review we will provide a general outline to the main approaches that are used in studies aiming to identify susceptibility genes for psychiatric disorders.
AB - Our understanding of the pathophysiology of the majority of common psychiatric disorders is limited, and in most cases the evidence for genetic risk factors remains our strongest clue to their cause. Their precise genetic architecture is however largely unknown but is likely to be complex, with the phenotype being a result of interactions between multiple genetic and environmental factors. Consequently each DNA variant will inevitably have a modest effect on disease risk. In this review we will provide a general outline to the main approaches that are used in studies aiming to identify susceptibility genes for psychiatric disorders.
KW - association
KW - basic sciences
KW - complex traits
KW - genetic mapping
KW - linkage
KW - neuropsychiatry
KW - whole genome
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UR - http://www.scopus.com/inward/citedby.url?scp=77950205081&partnerID=8YFLogxK
U2 - 10.1383/psyt.2005.4.12.22
DO - 10.1383/psyt.2005.4.12.22
M3 - Article
VL - 4
SP - 22
EP - 26
JO - Psychiatry
JF - Psychiatry
SN - 1476-1793
IS - 12
ER -