TY - JOUR
T1 - Genetic linkage and imprinting effects on body mass index in children and young adults
AU - Gorlova, Olga Y.
AU - Amos, Christopher I.
AU - Wang, Nancy W.
AU - Shete, Sanjay
AU - Turner, Stephen T.
AU - Boerwinkle, Eric
N1 - Funding Information:
The study was supported by Grants HL51021, ES09912, and HG02275.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Body mass index (BMI) is used as a measure of fatness. Here we performed a genome-wide scan for genes related to BMI, while allowing for the possible effects of imprinting. We applied a sib pair linkage analysis to a sample of primarily children and young adults by using the Haseman-Elston method, which we modified to model the separate effects of paternally and maternally derived genetic factors. After stratification of sib pairs according to age, a number of regions showing linkage with BMI were identified. Most linkage and imprinting effects were found in children 5-11 years of age. Strongest evidences for linkage in children were found on chromosome 20 at 20p 11.2-pter near the marker D20S851 (LODTotal= 4.08, P= 0.000046) and near the marker D20S482 (LODTotal = 3.55, P= 0.00016), and Chromosome 16 at 16p 13 near the marker ATA41E04 (LODTotal = 3.12, P= 0.00025), and those loci did not show significant evidence for imprinting. Six regions showing evidence of imprinting were 3p23-p24 (paternal expression), 4q31.1-q32 (maternal expression), 10p14-q11 (paternal expression), and 12p12-pter (paternal expression) in children, and 4q31-qter (paternal expression) and 8p (paternal expression) in adults.
AB - Body mass index (BMI) is used as a measure of fatness. Here we performed a genome-wide scan for genes related to BMI, while allowing for the possible effects of imprinting. We applied a sib pair linkage analysis to a sample of primarily children and young adults by using the Haseman-Elston method, which we modified to model the separate effects of paternally and maternally derived genetic factors. After stratification of sib pairs according to age, a number of regions showing linkage with BMI were identified. Most linkage and imprinting effects were found in children 5-11 years of age. Strongest evidences for linkage in children were found on chromosome 20 at 20p 11.2-pter near the marker D20S851 (LODTotal= 4.08, P= 0.000046) and near the marker D20S482 (LODTotal = 3.55, P= 0.00016), and Chromosome 16 at 16p 13 near the marker ATA41E04 (LODTotal = 3.12, P= 0.00025), and those loci did not show significant evidence for imprinting. Six regions showing evidence of imprinting were 3p23-p24 (paternal expression), 4q31.1-q32 (maternal expression), 10p14-q11 (paternal expression), and 12p12-pter (paternal expression) in children, and 4q31-qter (paternal expression) and 8p (paternal expression) in adults.
KW - Age grouping
KW - BMI
KW - Imprinting
KW - Linkage
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U2 - 10.1038/sj.ejhg.5200979
DO - 10.1038/sj.ejhg.5200979
M3 - Article
C2 - 12774034
AN - SCOPUS:0038040484
SN - 1018-4813
VL - 11
SP - 425
EP - 432
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
IS - 6
ER -