Genetic linkage and imprinting effects on body mass index in children and young adults

Olga Y. Gorlova, Christopher I. Amos, Nancy W. Wang, Sanjay Shete, Stephen T Turner, Eric Boerwinkle

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Body mass index (BMI) is used as a measure of fatness. Here we performed a genome-wide scan for genes related to BMI, while allowing for the possible effects of imprinting. We applied a sib pair linkage analysis to a sample of primarily children and young adults by using the Haseman-Elston method, which we modified to model the separate effects of paternally and maternally derived genetic factors. After stratification of sib pairs according to age, a number of regions showing linkage with BMI were identified. Most linkage and imprinting effects were found in children 5-11 years of age. Strongest evidences for linkage in children were found on chromosome 20 at 20p 11.2-pter near the marker D20S851 (LODTotal= 4.08, P= 0.000046) and near the marker D20S482 (LODTotal = 3.55, P= 0.00016), and Chromosome 16 at 16p 13 near the marker ATA41E04 (LODTotal = 3.12, P= 0.00025), and those loci did not show significant evidence for imprinting. Six regions showing evidence of imprinting were 3p23-p24 (paternal expression), 4q31.1-q32 (maternal expression), 10p14-q11 (paternal expression), and 12p12-pter (paternal expression) in children, and 4q31-qter (paternal expression) and 8p (paternal expression) in adults.

Original languageEnglish (US)
Pages (from-to)425-432
Number of pages8
JournalEuropean Journal of Human Genetics
Volume11
Issue number6
DOIs
StatePublished - Jun 1 2003

Fingerprint

Genomic Imprinting
Genetic Linkage
Young Adult
Body Mass Index
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 16
Mothers
Genome
Genes

Keywords

  • Age grouping
  • BMI
  • Imprinting
  • Linkage

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Genetic linkage and imprinting effects on body mass index in children and young adults. / Gorlova, Olga Y.; Amos, Christopher I.; Wang, Nancy W.; Shete, Sanjay; Turner, Stephen T; Boerwinkle, Eric.

In: European Journal of Human Genetics, Vol. 11, No. 6, 01.06.2003, p. 425-432.

Research output: Contribution to journalArticle

Gorlova, Olga Y. ; Amos, Christopher I. ; Wang, Nancy W. ; Shete, Sanjay ; Turner, Stephen T ; Boerwinkle, Eric. / Genetic linkage and imprinting effects on body mass index in children and young adults. In: European Journal of Human Genetics. 2003 ; Vol. 11, No. 6. pp. 425-432.
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