Genetic linkage and imprinting effects on body mass index in children and young adults

Olga Y. Gorlova, Christopher I. Amos, Nancy W. Wang, Sanjay Shete, Stephen T. Turner, Eric Boerwinkle

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Body mass index (BMI) is used as a measure of fatness. Here we performed a genome-wide scan for genes related to BMI, while allowing for the possible effects of imprinting. We applied a sib pair linkage analysis to a sample of primarily children and young adults by using the Haseman-Elston method, which we modified to model the separate effects of paternally and maternally derived genetic factors. After stratification of sib pairs according to age, a number of regions showing linkage with BMI were identified. Most linkage and imprinting effects were found in children 5-11 years of age. Strongest evidences for linkage in children were found on chromosome 20 at 20p 11.2-pter near the marker D20S851 (LODTotal= 4.08, P= 0.000046) and near the marker D20S482 (LODTotal = 3.55, P= 0.00016), and Chromosome 16 at 16p 13 near the marker ATA41E04 (LODTotal = 3.12, P= 0.00025), and those loci did not show significant evidence for imprinting. Six regions showing evidence of imprinting were 3p23-p24 (paternal expression), 4q31.1-q32 (maternal expression), 10p14-q11 (paternal expression), and 12p12-pter (paternal expression) in children, and 4q31-qter (paternal expression) and 8p (paternal expression) in adults.

Original languageEnglish (US)
Pages (from-to)425-432
Number of pages8
JournalEuropean Journal of Human Genetics
Volume11
Issue number6
DOIs
StatePublished - Jun 1 2003

Keywords

  • Age grouping
  • BMI
  • Imprinting
  • Linkage

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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