Genetic immunization

Applying recombinant DNA technology in the immune system to develop new vaccines

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Genetic immunization iS a new method for vaccine development where the gene for an antigen is introduced into the host, such that the host cells produce vaccine antigens in vivo. By producing antigens intracellularly, genetic immunization is able to produce protective cellular immune responses as well as antibody responses to combat pathogens and cancer. Because genetic vaccines consist of plasmid DNA, the fundamental character of this vaccine can be manipulated at will by simple recombinant DNA techniques. This ability to easily modify and test novel vaccines combined with the power to drive both arms of the immune system, gives this technology a unique potential unavailable to other vaccines to combat the most difficult of disease targets. This review will discuss the current and future applications of this technology.

Original languageEnglish (US)
Pages (from-to)118-128
Number of pages11
JournalCurrent Opinion in Drug Discovery and Development
Volume2
Issue number2
StatePublished - 1999
Externally publishedYes

Fingerprint

Recombinant DNA
Immune System
Immunization
Vaccines
Technology
Antigens
Combined Vaccines
Cellular Immunity
Antibody Formation
Plasmids
DNA
Genes
Neoplasms

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Pharmacology

Cite this

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