Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease

J. I. Rotter, Gloria M Petersen, I. M. Samloff, R. B. McConnell, A. Ellis, M. A. Spence, D. L. Rimoin

Research output: Contribution to journalArticle

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Abstract

In a search for a genetic marker of duodenal ulcer, we measured serum pepsinogen I levels in 168 ulcer patients and 151 of their clinically normal siblings. The ulcer patients tended to have either hyperpepsinogenemia I (pepsinogen I, ≥ 100 ng/mL) or a normal level on a familial basis. Further evidence supporting this separation was the finding that the mean serum pepsinogen I level in the clinically normal siblings of the hyperpepsinogenemic patients was 91.2 ng/mL, significantly higher than the mean level (63.1 ng/mL) in the normal siblings of the normopepsinogenemic I patients. In the hyperpepsinogenemic I families the results of segregation analysis of an elevated pepsinogen I were consistent with autosomal-dominant inheritance of this trait. The genetic basis of normopepsinogenemic I duodenal ulcer was also shown by the familial aggregation of this disorder. These data provide direct evidence for genetic heterogeneity of duodenal ulcer disease.

Original languageEnglish (US)
Pages (from-to)372-377
Number of pages6
JournalAnnals of Internal Medicine
Volume91
Issue number3
StatePublished - 1979
Externally publishedYes

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Duodenal Diseases
Pepsinogen A
Genetic Heterogeneity
Duodenal Ulcer
Siblings
Ulcer
Serum
Genetic Markers

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rotter, J. I., Petersen, G. M., Samloff, I. M., McConnell, R. B., Ellis, A., Spence, M. A., & Rimoin, D. L. (1979). Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease. Annals of Internal Medicine, 91(3), 372-377.

Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease. / Rotter, J. I.; Petersen, Gloria M; Samloff, I. M.; McConnell, R. B.; Ellis, A.; Spence, M. A.; Rimoin, D. L.

In: Annals of Internal Medicine, Vol. 91, No. 3, 1979, p. 372-377.

Research output: Contribution to journalArticle

Rotter, JI, Petersen, GM, Samloff, IM, McConnell, RB, Ellis, A, Spence, MA & Rimoin, DL 1979, 'Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease', Annals of Internal Medicine, vol. 91, no. 3, pp. 372-377.
Rotter, J. I. ; Petersen, Gloria M ; Samloff, I. M. ; McConnell, R. B. ; Ellis, A. ; Spence, M. A. ; Rimoin, D. L. / Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease. In: Annals of Internal Medicine. 1979 ; Vol. 91, No. 3. pp. 372-377.
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