Genetic Factors in Acute Myeloid Leukemia with Myelodysplasia-Related Changes

Hong Fang, Rong He, April Chiu, David S. Viswanatha, Rhett P. Ketterling, Mrinal S. Patnaik, Kaaren K. Reichard

Research output: Contribution to journalArticle

Abstract

Objectives: Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous category with a broad range of underlying genetic abnormalities. We investigated the significance of genetic factors in a large series of AML-MRC cases. Methods: The morphologic findings, genetic data, and patient outcomes were assessed in 186 AML-MRC cases. Results: The median overall survival (OS) was dismal in AML-MRC patients (median, 7.6 months; 95% confidence interval, 5-10.6 months). Karyotypically normal cases and cytogenetically abnormal cases without myelodysplastic syndrome (MDS)-related cytogenetic abnormalities showed similar OS, significantly better than cases carrying MDS-related cytogenetic abnormalities. MDS-related cytogenetic abnormalities, monosomal or complex karyotype, and history of MDS or myelodysplastic/myeloproliferative neoplasm were all associated with dismal outcome. Conclusions: AML-MRC predicts a poor prognosis. Our study supports the finding that the genetic profile plays a key role in determining prognosis in AML-MRC as defined according to the World Health Organization revised fourth edition (2017) diagnostic criteria.

Original languageEnglish (US)
Pages (from-to)656-663
Number of pages8
JournalAmerican journal of clinical pathology
Volume153
Issue number5
DOIs
StatePublished - Apr 15 2020

Keywords

  • Acute myeloid leukemia
  • Genetics
  • Myelodysplasia-related changes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Fang, H., He, R., Chiu, A., Viswanatha, D. S., Ketterling, R. P., Patnaik, M. S., & Reichard, K. K. (2020). Genetic Factors in Acute Myeloid Leukemia with Myelodysplasia-Related Changes. American journal of clinical pathology, 153(5), 656-663. https://doi.org/10.1093/ajcp/aqz206