Genetic Factors in Acute Myeloid Leukemia with Myelodysplasia-Related Changes

Hong Fang; Rong He; April Chiu; David S. Viswanatha; Rhett P. Ketterling; Mrinal S. Patnaik; Kaaren K. Reichard

doi:10.1093/ajcp/aqz206

Genetic Factors in Acute Myeloid Leukemia with Myelodysplasia-Related Changes

Hong Fang, Rong He, April Chiu, David S. Viswanatha, Rhett P. Ketterling, Mrinal S. Patnaik, Kaaren K. Reichard

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objectives: Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous category with a broad range of underlying genetic abnormalities. We investigated the significance of genetic factors in a large series of AML-MRC cases. Methods: The morphologic findings, genetic data, and patient outcomes were assessed in 186 AML-MRC cases. Results: The median overall survival (OS) was dismal in AML-MRC patients (median, 7.6 months; 95% confidence interval, 5-10.6 months). Karyotypically normal cases and cytogenetically abnormal cases without myelodysplastic syndrome (MDS)-related cytogenetic abnormalities showed similar OS, significantly better than cases carrying MDS-related cytogenetic abnormalities. MDS-related cytogenetic abnormalities, monosomal or complex karyotype, and history of MDS or myelodysplastic/myeloproliferative neoplasm were all associated with dismal outcome. Conclusions: AML-MRC predicts a poor prognosis. Our study supports the finding that the genetic profile plays a key role in determining prognosis in AML-MRC as defined according to the World Health Organization revised fourth edition (2017) diagnostic criteria.

Original language	English (US)
Pages (from-to)	656-663
Number of pages	8
Journal	American journal of clinical pathology
Volume	153
Issue number	5
DOIs	https://doi.org/10.1093/ajcp/aqz206
State	Published - Apr 15 2020

Keywords

Acute myeloid leukemia
Genetics
Myelodysplasia-related changes

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1093/ajcp/aqz206

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title = "Genetic Factors in Acute Myeloid Leukemia with Myelodysplasia-Related Changes",

abstract = "Objectives: Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous category with a broad range of underlying genetic abnormalities. We investigated the significance of genetic factors in a large series of AML-MRC cases. Methods: The morphologic findings, genetic data, and patient outcomes were assessed in 186 AML-MRC cases. Results: The median overall survival (OS) was dismal in AML-MRC patients (median, 7.6 months; 95% confidence interval, 5-10.6 months). Karyotypically normal cases and cytogenetically abnormal cases without myelodysplastic syndrome (MDS)-related cytogenetic abnormalities showed similar OS, significantly better than cases carrying MDS-related cytogenetic abnormalities. MDS-related cytogenetic abnormalities, monosomal or complex karyotype, and history of MDS or myelodysplastic/myeloproliferative neoplasm were all associated with dismal outcome. Conclusions: AML-MRC predicts a poor prognosis. Our study supports the finding that the genetic profile plays a key role in determining prognosis in AML-MRC as defined according to the World Health Organization revised fourth edition (2017) diagnostic criteria.",

keywords = "Acute myeloid leukemia, Genetics, Myelodysplasia-related changes",

author = "Hong Fang and Rong He and April Chiu and Viswanatha, {David S.} and Ketterling, {Rhett P.} and Patnaik, {Mrinal S.} and Reichard, {Kaaren K.}",

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doi = "10.1093/ajcp/aqz206",

language = "English (US)",

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AU - Fang, Hong

AU - He, Rong

AU - Chiu, April

AU - Viswanatha, David S.

AU - Ketterling, Rhett P.

AU - Patnaik, Mrinal S.

AU - Reichard, Kaaren K.

PY - 2020/4/15

Y1 - 2020/4/15

N2 - Objectives: Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous category with a broad range of underlying genetic abnormalities. We investigated the significance of genetic factors in a large series of AML-MRC cases. Methods: The morphologic findings, genetic data, and patient outcomes were assessed in 186 AML-MRC cases. Results: The median overall survival (OS) was dismal in AML-MRC patients (median, 7.6 months; 95% confidence interval, 5-10.6 months). Karyotypically normal cases and cytogenetically abnormal cases without myelodysplastic syndrome (MDS)-related cytogenetic abnormalities showed similar OS, significantly better than cases carrying MDS-related cytogenetic abnormalities. MDS-related cytogenetic abnormalities, monosomal or complex karyotype, and history of MDS or myelodysplastic/myeloproliferative neoplasm were all associated with dismal outcome. Conclusions: AML-MRC predicts a poor prognosis. Our study supports the finding that the genetic profile plays a key role in determining prognosis in AML-MRC as defined according to the World Health Organization revised fourth edition (2017) diagnostic criteria.

AB - Objectives: Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous category with a broad range of underlying genetic abnormalities. We investigated the significance of genetic factors in a large series of AML-MRC cases. Methods: The morphologic findings, genetic data, and patient outcomes were assessed in 186 AML-MRC cases. Results: The median overall survival (OS) was dismal in AML-MRC patients (median, 7.6 months; 95% confidence interval, 5-10.6 months). Karyotypically normal cases and cytogenetically abnormal cases without myelodysplastic syndrome (MDS)-related cytogenetic abnormalities showed similar OS, significantly better than cases carrying MDS-related cytogenetic abnormalities. MDS-related cytogenetic abnormalities, monosomal or complex karyotype, and history of MDS or myelodysplastic/myeloproliferative neoplasm were all associated with dismal outcome. Conclusions: AML-MRC predicts a poor prognosis. Our study supports the finding that the genetic profile plays a key role in determining prognosis in AML-MRC as defined according to the World Health Organization revised fourth edition (2017) diagnostic criteria.

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Genetic Factors in Acute Myeloid Leukemia with Myelodysplasia-Related Changes

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