Genetic evidence for the involvement of τ in progressive supranuclear palsy

Chris Conrad; Athena Andreadis; John Q. Trojanowski; Dennis W. Dickson; David Kang; Xiaohua Chen; Wigbert Wiederholt; Larry Hansen; Eliezer Masliah; Leon J. Thal; Robert Katzman; Yu Xia; Tsunao Saitoh

doi:10.1002/ana.410410222

Genetic evidence for the involvement of τ in progressive supranuclear palsy

Chris Conrad, Athena Andreadis, John Q. Trojanowski, Dennis W. Dickson, David Kang, Xiaohua Chen, Wigbert Wiederholt, Larry Hansen, Eliezer Masliah, Leon J. Thal, Robert Katzman, Yu Xia, Tsunao Saitoh

Neuroscience

Research output: Contribution to journal › Article › peer-review

372 Scopus citations

Abstract

A dinucleotide repeat polymorphism in a τ intron was identified and used in a case-control study to analyze, the genetic association of τ with several neurodegenerative diseases with τ pathology. Subjects with the homozygous τ A0 alleles were excessively represented in the progressive supranuclear palsy (PSP) group, compared with the age-matched healthy control group. Consequently, this allele is more frequently found in PSP than in a group of healthy subjects. This trend was not found in Alzheimer's disease or parkinsonism-dementia complex of Guam, both of which are accompanied by major τ pathology. The result suggests a possible involvement of τ in the patbogenesis of PSP.

Original language	English (US)
Pages (from-to)	277-281
Number of pages	5
Journal	Annals of neurology
Volume	41
Issue number	2
DOIs	https://doi.org/10.1002/ana.410410222
State	Published - 1997

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Genetic evidence for the involvement of τ in progressive supranuclear palsy",

abstract = "A dinucleotide repeat polymorphism in a τ intron was identified and used in a case-control study to analyze, the genetic association of τ with several neurodegenerative diseases with τ pathology. Subjects with the homozygous τ A0 alleles were excessively represented in the progressive supranuclear palsy (PSP) group, compared with the age-matched healthy control group. Consequently, this allele is more frequently found in PSP than in a group of healthy subjects. This trend was not found in Alzheimer's disease or parkinsonism-dementia complex of Guam, both of which are accompanied by major τ pathology. The result suggests a possible involvement of τ in the patbogenesis of PSP.",

author = "Chris Conrad and Athena Andreadis and Trojanowski, {John Q.} and Dickson, {Dennis W.} and David Kang and Xiaohua Chen and Wigbert Wiederholt and Larry Hansen and Eliezer Masliah and Thal, {Leon J.} and Robert Katzman and Yu Xia and Tsunao Saitoh",

year = "1997",

doi = "10.1002/ana.410410222",

language = "English (US)",

volume = "41",

pages = "277--281",

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TY - JOUR

T1 - Genetic evidence for the involvement of τ in progressive supranuclear palsy

AU - Conrad, Chris

AU - Andreadis, Athena

AU - Trojanowski, John Q.

AU - Dickson, Dennis W.

AU - Kang, David

AU - Chen, Xiaohua

AU - Wiederholt, Wigbert

AU - Hansen, Larry

AU - Masliah, Eliezer

AU - Thal, Leon J.

AU - Katzman, Robert

AU - Xia, Yu

AU - Saitoh, Tsunao

PY - 1997

Y1 - 1997

N2 - A dinucleotide repeat polymorphism in a τ intron was identified and used in a case-control study to analyze, the genetic association of τ with several neurodegenerative diseases with τ pathology. Subjects with the homozygous τ A0 alleles were excessively represented in the progressive supranuclear palsy (PSP) group, compared with the age-matched healthy control group. Consequently, this allele is more frequently found in PSP than in a group of healthy subjects. This trend was not found in Alzheimer's disease or parkinsonism-dementia complex of Guam, both of which are accompanied by major τ pathology. The result suggests a possible involvement of τ in the patbogenesis of PSP.

AB - A dinucleotide repeat polymorphism in a τ intron was identified and used in a case-control study to analyze, the genetic association of τ with several neurodegenerative diseases with τ pathology. Subjects with the homozygous τ A0 alleles were excessively represented in the progressive supranuclear palsy (PSP) group, compared with the age-matched healthy control group. Consequently, this allele is more frequently found in PSP than in a group of healthy subjects. This trend was not found in Alzheimer's disease or parkinsonism-dementia complex of Guam, both of which are accompanied by major τ pathology. The result suggests a possible involvement of τ in the patbogenesis of PSP.

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Genetic evidence for the involvement of τ in progressive supranuclear palsy

Abstract

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