Genetic events in the pathogenesis of multiple myeloma

W. J. Chng, O. Glebov, P. L. Bergsagel, W. M. Kuehl

Research output: Contribution to journalReview article

143 Scopus citations

Abstract

The genetics of myeloma has been increasingly elucidated in recent years. Recurrent genetic events, and also biologically distinct and clinically relevant genetic subtypes of myeloma have been defined. This has facilitated our understanding of the molecular pathogenesis of the disease. In addition, some genetic abnormalities have proved to be highly reproducible prognostic factors. With the expanding therapeutic armamentarium, it is time to include genetic assessment as part of clinical evaluation of myeloma patients to guide management. In this review we examine the role of various genetic abnormalities in the molecular pathogenesis of myeloma, and the use of such abnormalities in disease classification, prognosis and clinical management.

Original languageEnglish (US)
Pages (from-to)571-596
Number of pages26
JournalBest Practice and Research: Clinical Haematology
Volume20
Issue number4
DOIs
StatePublished - Dec 1 2007

Keywords

  • IgH translocations
  • gene expression profiling
  • genetics
  • hyperdiploid
  • molecular pathogenesis
  • prognosis

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry

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