Genetic etiology of sporadic ovarian cancer

Ellen L Goode, Mine Cicek, Catherine M. Phelan, Brooke L. Fridley

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction Ovarian cancer presents as familial clusters and as sporadic cases without strong family history. As summarized elsewhere in this book, rare mutations conferring substantially increased ovarian cancer risk (up to 50%) occur in several genes including BRCA1 and BRCA2 [9,10], mismatch repair genes such as MLH1 and MSH2 [11], and other DNA repair genes, such as RAD51C [12]. Yet, these high-risk variants are very rare (less than 1% in most populations), and they are estimated to account for less than 40% of the excess familial risk of ovarian cancer [13]. Here, we describe the genetic etiology of sporadic ovarian cancer (i.e., ovarian cancers that do not arise from within high-risk familial clusters). We review evidence that ovarian cancer is genetic, data on particular genes which have been studied as candidates, results from searches throughout the genome for ovarian cancer risk factors, strategies for follow-up of genomic regions harboring risk loci, and approaches for the identification and characterization of additional genetic factors. Evidence for low-penetrance loci The role of inherited factors in ovarian cancer susceptibility is suggested by numerous epidemiologic studies reporting increased risks from 2- to 10-fold for women with family history of ovarian cancer [14]. In fact, compared with confirmed demographic, reproductive, and lifestyle factors, positive family history is the strongest risk factor for ovarian cancer. Increased familial risk can be explained, in part, by shared environmental factors; however, studies of twins and migrants provide additional support for genetic heritability of the disease. For example, identical twins are more likely to have the same ovarian cancer disease state than fraternal twins [15]. In addition, genetic epidemiologic models suggest that a large number of additional rare high-risk variants, such as BRCA1 or BRCA2 is unlikely to exist [16].

Original languageEnglish (US)
Title of host publicationAltchek's Diagnosis and Management of Ovarian Disorders, Third Edition
PublisherCambridge University Press
Pages141-150
Number of pages10
ISBN (Electronic)9781139003254
ISBN (Print)9781107012813
DOIs
StatePublished - Jan 1 2010

Fingerprint

Ovarian Neoplasms
Rare Books
BRCA2 Gene
Ovarian Diseases
BRCA1 Gene
Genes
Dizygotic Twins
Inborn Genetic Diseases
Twin Studies
DNA Mismatch Repair
Monozygotic Twins
Penetrance
Genetic Models
DNA Repair
Life Style
Epidemiologic Studies
Demography
Genome
Mutation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Goode, E. L., Cicek, M., Phelan, C. M., & Fridley, B. L. (2010). Genetic etiology of sporadic ovarian cancer. In Altchek's Diagnosis and Management of Ovarian Disorders, Third Edition (pp. 141-150). Cambridge University Press. https://doi.org/10.1017/CBO9781139003254.011

Genetic etiology of sporadic ovarian cancer. / Goode, Ellen L; Cicek, Mine; Phelan, Catherine M.; Fridley, Brooke L.

Altchek's Diagnosis and Management of Ovarian Disorders, Third Edition. Cambridge University Press, 2010. p. 141-150.

Research output: Chapter in Book/Report/Conference proceedingChapter

Goode, EL, Cicek, M, Phelan, CM & Fridley, BL 2010, Genetic etiology of sporadic ovarian cancer. in Altchek's Diagnosis and Management of Ovarian Disorders, Third Edition. Cambridge University Press, pp. 141-150. https://doi.org/10.1017/CBO9781139003254.011
Goode EL, Cicek M, Phelan CM, Fridley BL. Genetic etiology of sporadic ovarian cancer. In Altchek's Diagnosis and Management of Ovarian Disorders, Third Edition. Cambridge University Press. 2010. p. 141-150 https://doi.org/10.1017/CBO9781139003254.011
Goode, Ellen L ; Cicek, Mine ; Phelan, Catherine M. ; Fridley, Brooke L. / Genetic etiology of sporadic ovarian cancer. Altchek's Diagnosis and Management of Ovarian Disorders, Third Edition. Cambridge University Press, 2010. pp. 141-150
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AB - Introduction Ovarian cancer presents as familial clusters and as sporadic cases without strong family history. As summarized elsewhere in this book, rare mutations conferring substantially increased ovarian cancer risk (up to 50%) occur in several genes including BRCA1 and BRCA2 [9,10], mismatch repair genes such as MLH1 and MSH2 [11], and other DNA repair genes, such as RAD51C [12]. Yet, these high-risk variants are very rare (less than 1% in most populations), and they are estimated to account for less than 40% of the excess familial risk of ovarian cancer [13]. Here, we describe the genetic etiology of sporadic ovarian cancer (i.e., ovarian cancers that do not arise from within high-risk familial clusters). We review evidence that ovarian cancer is genetic, data on particular genes which have been studied as candidates, results from searches throughout the genome for ovarian cancer risk factors, strategies for follow-up of genomic regions harboring risk loci, and approaches for the identification and characterization of additional genetic factors. Evidence for low-penetrance loci The role of inherited factors in ovarian cancer susceptibility is suggested by numerous epidemiologic studies reporting increased risks from 2- to 10-fold for women with family history of ovarian cancer [14]. In fact, compared with confirmed demographic, reproductive, and lifestyle factors, positive family history is the strongest risk factor for ovarian cancer. Increased familial risk can be explained, in part, by shared environmental factors; however, studies of twins and migrants provide additional support for genetic heritability of the disease. For example, identical twins are more likely to have the same ovarian cancer disease state than fraternal twins [15]. In addition, genetic epidemiologic models suggest that a large number of additional rare high-risk variants, such as BRCA1 or BRCA2 is unlikely to exist [16].

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