Genetic epidemiology of colorectal cancer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Genetic epidemiological methods have played an integral role in the characterisation of the genetic susceptibilities to colorectal cancer. Classic epidemiological approaches, such as case-control and prospective cohort studies, that utilise family history information have laid the foundation for the more specialised family-based genetic methods, segregation analysis and linkage analysis. The genetic epidemiology of colorectal cancer can be characterised by several themes: the consistently increased risk of colorectal cancer in first-degree relatives of patients with colorectal cancer; genetic predisposition to some, if not the majority of colorectal neoplasms; and genetic heterogeneity of the inherited colorectal cancer syndromes. With the rapid development of molecular genetic techniques, new opportunities for further research include studies to estimate the proportion of colorectal cancer that is accounted for by genetic susceptibility, the number of loci that may be involved, and most importantly, gene-environment interaction studies, not only of the inherited syndromes, but of common colorectal cancer.

Original languageEnglish (US)
Pages (from-to)1047-1050
Number of pages4
JournalEuropean Journal of Cancer
Volume31
Issue number7-8
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Molecular Epidemiology
Colorectal Neoplasms
Genetic Predisposition to Disease
Epidemiologic Methods
Genetic Techniques
Gene-Environment Interaction
Genetic Heterogeneity
Molecular Biology
Cohort Studies
Prospective Studies
Research

Keywords

  • colon
  • family history
  • genetic analysis
  • susceptibility

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Hematology

Cite this

Genetic epidemiology of colorectal cancer. / Petersen, Gloria M.

In: European Journal of Cancer, Vol. 31, No. 7-8, 1995, p. 1047-1050.

Research output: Contribution to journalArticle

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