Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV

LongJun Wu, Xue Han Zhang, Hotaka Fukushima, Fuxing Zhang, Hansen Wang, Hiroki Toyoda, Bao Ming Li, Satoshi Kida, Min Zhuo

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Long-term potentiation (LTP) is a key cellular model for studying mechanisms for learning and memory. Previous studies reported that the Ca 2+/calmodulin-dependent protein kinase IV (CaMKIV) is critical for gene regulation, and behavioral learning and memory. Less is known about the roles of CaMKIV in cortical plasticity and trace fear memory. Here we have found that LTP was significantly enhanced in the anterior cingulate cortex (ACC) of the mice overexpressing CaMKIV. By contrast, neither α-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated basal excitatory synaptic transmission nor N-methyl-d-aspartate (NMDA) receptor-mediated excitatory postsynaptic currents were affected. Furthermore, paired-pulse ratio in the transgenic mice is normal. In behavioral tests, we found that the CaMKIV transgenic mice exhibited significant enhancement in trace fear memory, while the acute sensory thresholds were not affected. Our results provide strong evidence that forebrain CaMKIV contributes to trace fear memory by enhancing synaptic potentiation in the ACC.

Original languageEnglish (US)
Pages (from-to)1923-1932
Number of pages10
JournalEuropean Journal of Neuroscience
Volume27
Issue number8
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Fingerprint

Genetic Enhancement
Calcium-Calmodulin-Dependent Protein Kinase Type 4
Fear
Long-Term Potentiation
Gyrus Cinguli
Transgenic Mice
Learning
Sensory Thresholds
Calcium-Calmodulin-Dependent Protein Kinases
AMPA Receptors
Excitatory Postsynaptic Potentials
Prosencephalon
Synaptic Transmission
Acids
Genes

Keywords

  • Anterior cingulate cortex
  • CaMKIV
  • Long-term potentiation
  • Trace fear memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. / Wu, LongJun; Zhang, Xue Han; Fukushima, Hotaka; Zhang, Fuxing; Wang, Hansen; Toyoda, Hiroki; Li, Bao Ming; Kida, Satoshi; Zhuo, Min.

In: European Journal of Neuroscience, Vol. 27, No. 8, 01.04.2008, p. 1923-1932.

Research output: Contribution to journalArticle

Wu, LongJun ; Zhang, Xue Han ; Fukushima, Hotaka ; Zhang, Fuxing ; Wang, Hansen ; Toyoda, Hiroki ; Li, Bao Ming ; Kida, Satoshi ; Zhuo, Min. / Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. In: European Journal of Neuroscience. 2008 ; Vol. 27, No. 8. pp. 1923-1932.
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