Genetic data: The new challenge of personalized medicine, insights for rheumatoid arthritis patients

George N. Goulielmos, Maria I. Zervou, Effie Myrthianou, Agata Burska, Timothy B. Niewold, Frederique Ponchel

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Rapid advances in genotyping technology, analytical methods, and the establishment of large cohorts for population genetic studies have resulted in a large new body of information about the genetic basis of human rheumatoid arthritis (RA). Improved understanding of the root pathogenesis of the disease holds the promise of improved diagnostic and prognostic tools based upon this information. In this review, we summarize the nature of new genetic findings in human RA, including susceptibility loci and gene-gene and gene-environment interactions, as well as genetic loci associated with sub-groups of patients and those associated with response to therapy. Possible uses of these data are discussed, such as prediction of disease risk as well as personalized therapy and prediction of therapeutic response and risk of adverse events. While these applications are largely not refined to the point of clinical utility in RA, it seems likely that multi-parameter datasets including genetic, clinical, and biomarker data will be employed in the future care of RA patients.

Original languageEnglish (US)
Pages (from-to)90-101
Number of pages12
JournalGene
Volume583
Issue number2
DOIs
StatePublished - Jun 1 2016

    Fingerprint

Keywords

  • Gene polymorphisms
  • Genotyping technologies
  • Personalized medicine
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Genetics

Cite this

Goulielmos, G. N., Zervou, M. I., Myrthianou, E., Burska, A., Niewold, T. B., & Ponchel, F. (2016). Genetic data: The new challenge of personalized medicine, insights for rheumatoid arthritis patients. Gene, 583(2), 90-101. https://doi.org/10.1016/j.gene.2016.02.004