TY - JOUR
T1 - Genetic counseling and predictive testing for colorectal cancer risk
AU - Petersen, Gloria M.
PY - 1996/2/20
Y1 - 1996/2/20
N2 - In contrast to our rapidly increasing knowledge of the genetic basis of colorectal cancer and new molecular technologies, we are only in the early stages of characterizing the impact that this information will have on patients, their families and society. From our research and clinical experience with hereditary colorectal cancer syndromes, we have developed a framework for risk assessment that includes criteria for identifying those at higher genetic risk and guidelines for genetic counseling, predictive genetic testing and follow-up management. More research is needed to optimally translate this framework into wider clinical practice, including characterizing genetic heterogeneity and phenotype correlations, documenting the efficacy of screening and surgical interventions, and maximizing the awareness of health professionals on genetic counseling and the promise and limitations of gene tests.
AB - In contrast to our rapidly increasing knowledge of the genetic basis of colorectal cancer and new molecular technologies, we are only in the early stages of characterizing the impact that this information will have on patients, their families and society. From our research and clinical experience with hereditary colorectal cancer syndromes, we have developed a framework for risk assessment that includes criteria for identifying those at higher genetic risk and guidelines for genetic counseling, predictive genetic testing and follow-up management. More research is needed to optimally translate this framework into wider clinical practice, including characterizing genetic heterogeneity and phenotype correlations, documenting the efficacy of screening and surgical interventions, and maximizing the awareness of health professionals on genetic counseling and the promise and limitations of gene tests.
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U2 - 10.1002/(SICI)1097-0215(19960220)69:1<53::AID-IJC13>3.0.CO;2-L
DO - 10.1002/(SICI)1097-0215(19960220)69:1<53::AID-IJC13>3.0.CO;2-L
M3 - Article
C2 - 8600062
AN - SCOPUS:0029974661
SN - 0020-7136
VL - 69
SP - 53
EP - 54
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 1
ER -