GENETIC CONTROL OF THE IMMUNE RESPONSE TO HEN'S EGG‐WHITE LYSOZYME IN MICE: I. ANTIBODY AND T‐LYMPHOCYTE PROLIFERATIVE RESPONSES TO THE NATIVE PROTEIN

We have initiated studies to determine whether the antibody and T‐lymphocyte proliferative responses to lysozyme and its antigenic sites is genetically controlled in mice. Mice of the H‐2^f, H‐2^k and H‐2^p were high responders, while haplotypes H‐2^b, H‐2^d, H‐2^r and H‐2^s were low responders. Studies with recombinants indicated that the immune response is controlled by two H‐2I region loci, one being in the I‐A subregion and the other may be in the I‐C subregions.