GENETIC CONTROL OF THE IMMUNE RESPONSE TO HEN'S EGG‐WHITE LYSOZYME IN MICE: I. ANTIBODY AND T‐LYMPHOCYTE PROLIFERATIVE RESPONSES TO THE NATIVE PROTEIN

K. Okuda, S. Sakata, M. Zouhair Atassi, C. S. David

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We have initiated studies to determine whether the antibody and T‐lymphocyte proliferative responses to lysozyme and its antigenic sites is genetically controlled in mice. Mice of the H‐2f, H‐2k and H‐2p were high responders, while haplotypes H‐2b, H‐2d, H‐2r and H‐2s were low responders. Studies with recombinants indicated that the immune response is controlled by two H‐2I region loci, one being in the I‐A subregion and the other may be in the I‐C subregions.

Original languageEnglish (US)
Pages (from-to)447-452
Number of pages6
JournalInternational Journal of Immunogenetics
Volume6
Issue number6
DOIs
StatePublished - Dec 1979

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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