Genetic control of the immune response to hen's egg-white lysozyme in mice. I. Antibody and T-lymphocyte proliferative responses to the native protein

K. Okuda, S. Sakata, M. Zouhair Atassi, C. S. David

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28 Citations (Scopus)

Abstract

We have initiated studies to determine whether the antibody and T-lymphocyte proliferative responses to lysozyme and its antigenic sites is genetically controlled in mice. Mice of the H-2(f), H-2(k) and H-2(p) were high responders, while haplotypes H-2(b), H-2(d), H-2(r) and H-2(s) were low responders. Studies with recombinants indicated that the immune response is controlled by two H-2I region loci, one being in the I-A subregion and the other may be in the I-C subregions.

Original languageEnglish (US)
Pages (from-to)447-452
Number of pages6
JournalJournal of Immunogenetics
Volume6
Issue number6
StatePublished - 1979

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Egg White
T-Lymphocytes
Antibodies
Muramidase
Haplotypes
Proteins
hen egg lysozyme

ASJC Scopus subject areas

  • Genetics
  • Immunology

Cite this

Genetic control of the immune response to hen's egg-white lysozyme in mice. I. Antibody and T-lymphocyte proliferative responses to the native protein. / Okuda, K.; Sakata, S.; Zouhair Atassi, M.; David, C. S.

In: Journal of Immunogenetics, Vol. 6, No. 6, 1979, p. 447-452.

Research output: Contribution to journalArticle

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