GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN: V. PRODUCTION AND CHARACTERIZATION OF Aβ RESTRICTED T CELL LINES AND CLONES

C. J. Krco, Ellen J. Abramson, N. Yoshoka, M. Z. Atassi, C. S. David

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Monoclonal anti‐Ia inhibition experiments were conducted to confirm and extend genetic mapping data of I‐A gene control of immunity to human haemoglobin (Hb). It was found that the Aβ gene is of critical importance in conferring immunity to the α‐chain and β‐chain subunits of Hb. A possible involvement of I‐E region genes in B10.D2 mice to β‐chain is discussed. Through the use of an α‐chain specific T cell clone data, is obtained indicating that an intact Ia.8+ Aβ chain is necessary for antigen presentation in vitro.

Original languageEnglish (US)
Pages (from-to)33-43
Number of pages11
JournalInternational Journal of Immunogenetics
Volume11
Issue number1
DOIs
StatePublished - Feb 1984

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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