GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN: V. PRODUCTION AND CHARACTERIZATION OF Aβ RESTRICTED T CELL LINES AND CLONES

C. J. Krco; Ellen J. Abramson; N. Yoshoka; M. Z. Atassi; C. S. David

doi:10.1111/j.1744-313X.1984.tb01037.x

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN: V. PRODUCTION AND CHARACTERIZATION OF A_β RESTRICTED T CELL LINES AND CLONES

C. J. Krco, Ellen J. Abramson, N. Yoshoka, M. Z. Atassi, C. S. David

Immunology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Monoclonal anti‐Ia inhibition experiments were conducted to confirm and extend genetic mapping data of I‐A gene control of immunity to human haemoglobin (Hb). It was found that the A_β gene is of critical importance in conferring immunity to the α‐chain and β‐chain subunits of Hb. A possible involvement of I‐E region genes in B10.D2 mice to β‐chain is discussed. Through the use of an α‐chain specific T cell clone data, is obtained indicating that an intact Ia.8⁺ A_β chain is necessary for antigen presentation in vitro.

Original language	English (US)
Pages (from-to)	33-43
Number of pages	11
Journal	International Journal of Immunogenetics
Volume	11
Issue number	1
DOIs	https://doi.org/10.1111/j.1744-313X.1984.tb01037.x
State	Published - Feb 1984

ASJC Scopus subject areas

Immunology
Molecular Biology
Genetics
Genetics(clinical)

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10.1111/j.1744-313X.1984.tb01037.x

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abstract = "Monoclonal anti‐Ia inhibition experiments were conducted to confirm and extend genetic mapping data of I‐A gene control of immunity to human haemoglobin (Hb). It was found that the Aβ gene is of critical importance in conferring immunity to the α‐chain and β‐chain subunits of Hb. A possible involvement of I‐E region genes in B10.D2 mice to β‐chain is discussed. Through the use of an α‐chain specific T cell clone data, is obtained indicating that an intact Ia.8+ Aβ chain is necessary for antigen presentation in vitro.",

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AU - David, C. S.

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