Genetic control of the immune response to haemoglobin. IV. Ly-1+ T-cells and appropriate non-H-2 genes are required for in vitro responses to α- and β-subunits of human adult haemoglobin

C. J. Krco, A. L. Kazim, M. Z. Atassi, C. S. David

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Abstract

Experiments were conducted to determine if non-H-2 gene effects could be demonstrated in mice which had been primed to either the α-subunit or β-subunit of human haemoglobin. It was found that C3H.SW [H-2(b)] and Balb/c [H-2(d)] mice are low responder mice to α-chain of a haemoglobin when compared to H-2 identical B10 [H-2(b)] and B10.D2 [H-2(d)] mice. B120.S and A.SW [both H-2(s)] are responsive to β-chain challenge while Balb/c mice are low responders in contrast to high responder B10.D2 mice. Ly-1+ cells were demonstrated to be required (by cell depletion experiments) for an in vitro T-cell proliferative response to either subunit. In these experiments, Ly-2+ cells were not of crucial importance.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalJournal of Immunogenetics
Volume9
Issue number2
StatePublished - 1982

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Hemoglobins
T-Lymphocytes
Genes
Hemoglobin Subunits
In Vitro Techniques

ASJC Scopus subject areas

  • Genetics
  • Immunology

Cite this

Genetic control of the immune response to haemoglobin. IV. Ly-1+ T-cells and appropriate non-H-2 genes are required for in vitro responses to α- and β-subunits of human adult haemoglobin. / Krco, C. J.; Kazim, A. L.; Atassi, M. Z.; David, C. S.

In: Journal of Immunogenetics, Vol. 9, No. 2, 1982, p. 93-100.

Research output: Contribution to journalArticle

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