Genetic control of immunoglobulin allotypes in the fowl

C. S. David, M. L. Kaeberle, A. W. Nordskog

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Abstract

Eight immunoglobulin allotypic specificities have been identified in the fowl by isoimmunization. Aa1 and Aa2 are controlled as codominants at the a locus, Ab1 and Ab2 at the b locus, and Ac1, Ac2, Ac3, and Ac4 at the c locus. Column chromatography and ultracentrifugation indicate that the specificities at the a locus are located on molecules corresponding to IgG with sedimentation coefficients 7 S. Immunoelectrophoresis results also indicate that we are dealing with an immunoglobulin G molecule. Further tests are underway to resolve this beyond doubt.

Original languageEnglish (US)
Pages (from-to)197-206
Number of pages10
JournalBiochemical Genetics
Volume3
Issue number2
DOIs
StatePublished - Apr 1 1969

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ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

David, C. S., Kaeberle, M. L., & Nordskog, A. W. (1969). Genetic control of immunoglobulin allotypes in the fowl. Biochemical Genetics, 3(2), 197-206. https://doi.org/10.1007/BF00520354