Genetic control of immunity to Heligmosomoides polygyrus: Presentation of promiscuous antigens to parasite-specific T cell hybridomas

Stephanie D. Mason, Thomas R. Gustad, Chella S. David, Michael Robinson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The role of MHC class II in the presentation of Heligmosomoides polygyrus antigens has been investigated, using a number of T cell hybridomas produced in A and E positive and negative mice. By using fixed and irradiated antigen presenting cells (APC), further evidence has emerged, to support earlier data, that there can be differential processing requirements during the presentation of H. polygyrus antigens by A and E molecules. In concordance with these earlier observations, this work provides further evidence that individual T cells can respond to antigen when presented by more than one MHC molecule. Previously, this evidence has been restricted to individual MHC molecules of the same haplotype, but these data show that H. polygyrus produces antigens which can be presented by both syngeneic and allogeneic MHC molecules. These antigens do not appear to be synonymous with the previously described H. polygyrus superantigen, as presentation is restricted to specific MHC haplotypes. It is proposed that H. polygyrus may produce these antigenic molecules as part of its strategy to manipulate the host immune system.

Original languageEnglish (US)
Pages (from-to)449-456
Number of pages8
JournalParasite Immunology
Volume18
Issue number9
DOIs
StatePublished - Sep 1996

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Keywords

  • Heligmosomoides polygyrus
  • MHC
  • Promiscuous antigens

ASJC Scopus subject areas

  • Parasitology
  • Immunology

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