Genetic control of immunity to Heligmosomoides polygyrus: fixed H‐2 E positive but not H‐2 negative cells can present antigen to a parasite‐specific T cell hybridoma

MICHAEL ROBINSON, THOMAS R. GUSTAD, STEPHANIE D. GARNER, CHELLA S. DAVID

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A number of T cell hybridomas were produced to adult worm homogenate (AWH) antigen of the nematode parasite Heligmosomoides polygyrus. All of the hybridomas were of the H‐2d haplotype and could potentially accept antigen in the context of either the Ad or Ed, H‐2 molecules. Three types of antigen presentation were observed, with some of the T cell hybridomas accepting antigen in the context of the E and some in the context of the A molecule. A third type of hybridoma responded to antigen presented by paraformaldehyde fixed APC, but only when APCs were Epositive. These same hybridomas, were however, stimulated by A WH, when the antigen was presented by syngeneic but unfixed, E positive or E negative A PC. Therefore these data indicate that certain H. polygyrus‐specfic T cell hybridomas can accept parasite antigen when presented in the context of either the H‐2 A or E molecule, but the presentation of antigen by the two different MHC Class II molecules, can apparently utilize differing processing mechanisms.,

Original languageEnglish (US)
Pages (from-to)237-243
Number of pages7
JournalParasite Immunology
Volume17
Issue number5
DOIs
StatePublished - May 1995

Keywords

  • H. polygyrus
  • MHC
  • antigen‐presentation
  • nematode

ASJC Scopus subject areas

  • Parasitology
  • Immunology

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