Genetic control of experimental autoimmune myasthenia gravis in mice. I. Lymphocyte proliferative response to acetylcholine receptor is under H-2-linked Ir gene control

P. Christacloss, Vanda A Lennon, C. David

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Abstract

As a first step in determining the genetic control of experimental autoimmune myasthenia gravis in mice, we tested the proliferative responses of lymph node cells to torpedo acetylcholine receptors (TAR). Studies with congenic and recombinant inbred strains of mice revealed that T-cell responses to TAR are controlled by an H-2-linked Ir gene, mapping in the I-A subregion of mouse major histocompatibility complex.

Original languageEnglish (US)
Pages (from-to)2540-2543
Number of pages4
JournalJournal of Immunology
Volume123
Issue number6
StatePublished - 1979

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Autoimmune Experimental Myasthenia Gravis
Torpedo
Cholinergic Receptors
Lymphocytes
Inbred Strains Mice
Chromosome Mapping
Major Histocompatibility Complex
Genes
Lymph Nodes
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

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abstract = "As a first step in determining the genetic control of experimental autoimmune myasthenia gravis in mice, we tested the proliferative responses of lymph node cells to torpedo acetylcholine receptors (TAR). Studies with congenic and recombinant inbred strains of mice revealed that T-cell responses to TAR are controlled by an H-2-linked Ir gene, mapping in the I-A subregion of mouse major histocompatibility complex.",
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